24 MPG combined is respectable fuel economy for the 2023 Mercedes-Benz E450 4matic All-Terrain, but it’s not the main reason people buy this wagon. Buyers want its mix of luxury, comfort, refined performance, and utility, accepting the fuel consumption as a trade-off. This isn’t a commuter car, it’s a premium lifestyle vehicle that can haul skis or luggage.

City and highway performance

The EPA estimates the E450 All-Terrain will get 21 MPG in the city and 28 MPG on the highway. The city figure is based on stop-and-go driving, where the engine works harder. The higher highway number shows the efficiency of the 3.0L turbocharged inline-six and nine-speed automatic transmission, which optimizes fuel consumption at steady speeds. The engine’s torque means fewer downshifts, improving highway mileage.

Annual fuel cost

The EPA estimates the annual fuel cost for the 2023 Mercedes-Benz E450 4matic All-Terrain is $2,400. This is based on driving 15,000 miles per year and using national average fuel prices. Premium fuel is recommended for the best performance, and its higher price will affect costs. The $2,400 figure is a good comparison point, but individual spending will vary based on driving habits and local fuel prices.

Real-world expectations

EPA estimates are a benchmark, but your fuel economy will vary. Aggressive driving, heavy loads, roof racks, and tire pressure can all change fuel consumption. A slight decrease from the EPA numbers is normal with mixed driving. However, owners who accelerate smoothly, anticipate traffic, and keep proper tire inflation can often get close to the EPA’s figures. Understanding the car and adapting your driving is key.

How it compares

The Audi A6 allroad, a direct competitor, gets 22 MPG combined, 20 city, and 26 highway. Compared to luxury SUVs like the BMW X5 xDrive40i (23 MPG combined), the E450 All-Terrain has similar or slightly better fuel economy while delivering a more engaging driving experience and more cargo space than many SUVs. Other wagons are also important to consider; however, few offer the same luxury. The Volvo V90 Cross Country, offers similar utility but gets 25 MPG combined. All all Mercedes Benz fuel economy data can be found on our site. For those considering other E450 options, you can find additional E450 MPG across all years.

Tips to maximize efficiency

Use the E450 All-Terrain’s ECO driving mode. This changes the throttle response and shift points, optimizing the engine for fuel efficiency. Performance will be slightly less, but it can change fuel consumption, especially during city driving.

Check and maintain proper tire inflation. Underinflated tires increase rolling resistance, forcing the engine to work harder. Check the sticker on the driver’s side doorjamb for the right tire pressure, and check the pressure at least once a month.

Reduce unnecessary weight. Extra cargo or items on the roof rack affect fuel economy. Remove items that are not needed to reduce the load on the engine. The E450 all-terrain is a spacious wagon but it is not meant to be a permanent storage facility.

Drive smoothly and consistently. Avoid harsh acceleration and hard braking, these habits consume more fuel. Instead, anticipate traffic and keep a steady speed. Cruise control on the highway can also help keep a consistent pace and improve fuel economy.