The 2022 Mercedes-Benz E450 Coupe 3.0L 6-cyl gets an EPA-estimated 25 MPG combined. This may seem surprising since the car isn’t designed to be an economy vehicle. It’s a stylish two-door grand tourer built for comfortable long-distance drives and making a statement. E450 Coupe buyers prioritize luxury, performance, and appearance over saving gas, accepting this trade-off for the car’s unique features.

City and highway performance

The EPA also estimates the E450 Coupe gets 22 MPG in the city and 29 MPG on the highway. The city number reflects the higher fuel use from stop-and-go traffic, where the engine works harder to accelerate from a stop. The highway MPG shows how well the 3.0L inline-six engine and smooth-shifting 9-speed automatic transmission perform when keeping a steady speed. This makes the E450 Coupe good for long road trips, where its highway fuel economy can help you drive further between fill-ups.

Annual fuel cost

The EPA estimates the annual fuel cost for the 2022 Mercedes-Benz E450 Coupe at $2,300. This is based on driving 15,000 miles per year using fuel prices that reflect the national average. Keep in mind that your actual fuel costs can change based on how you drive, local fuel prices, and the type of fuel you use. The E450 Coupe needs premium gasoline, which is usually more expensive than regular, and this will affect your total annual fuel expense.

Real-world expectations

EPA estimates are a standard benchmark, but real-world fuel economy often varies. Driving aggressively, taking many short trips, and carrying heavy loads can all hurt fuel consumption. However, if you accelerate smoothly, watch the traffic, and use the car’s fuel-saving features, you can often get mileage close to, or even better than, the EPA estimates. Watching your driving habits and the car’s feedback can help you get the best fuel efficiency.

How it compares

Comparing the E450 Coupe’s fuel economy to similar cars in its class can provide perspective. The BMW 440i Coupe, another sporty coupe, has similar performance and fuel economy, with an EPA-estimated 25 MPG combined for the rear-wheel-drive version. The Audi A5 Coupe with its 2.0-liter engine gets around 28 MPG combined, focusing slightly more on efficiency than power. The Lexus RC 350 gets around 23 MPG combined. Buyers in this group consider these differences along with styling, brand, and features. For those prioritizing fuel savings within the Mercedes-Benz family, be sure to see all Mercedes Benz fuel economy data.

Tips to maximize efficiency

The 2022 E450 Coupe has driving modes that can change fuel economy. “Eco” or “Comfort” mode often softens how the accelerator responds and makes the transmission shift to higher gears sooner, which decreases fuel use. Try out the different driving modes to find the right balance between performance and fuel efficiency for your driving.

Tire pressure is important for fuel economy. Underinflated tires create more rolling resistance, making the engine work harder and burn more fuel. Check and keep the correct tire pressure, as shown on the tire placard, to get the best efficiency and extend tire life. Use a good tire pressure gauge for accurate readings.

Reduce unnecessary weight in the car. Removing clutter and items you don’t need every day can slightly improve fuel economy. Extra weight puts more strain on the engine, increasing fuel use. This is especially important for a car like the E450, where buyers often value performance and acceleration.

Avoid aggressive driving habits like fast acceleration and hard braking. Smooth, gradual acceleration and watching traffic can greatly improve fuel economy. Keeping a steady speed on the highway is also more efficient than constantly speeding up and slowing down. Consider the E450 MPG across all years to see how driving habits have related to fuel efficiency on previous models.

The E450 Coupe is designed for premium gasoline. While you might want to use regular to save money, it could hurt the engine and reduce performance. Always use the fuel grade recommended to ensure the engine works well and achieve the best fuel efficiency, as specified by Mercedes-Benz.