The 2022 Mercedes-Benz E450 4matic Coupe gets 24 MPG combined. It’s not the most fuel-efficient car, but it’s designed as a stylish coupe that focuses on luxury and a refined driving experience. Fuel economy is a consideration, but probably not the main one for buyers who want elegance and performance.

City and highway performance

The EPA estimates the E450 Coupe will get 21 MPG in the city and 30 MPG on the highway. These numbers come from the car’s powertrain, a turbocharged 3.0-liter inline-six engine with a responsive 9-speed automatic transmission. This combination provides plenty of power for cruising and passing. Stop-and-go traffic hurts fuel consumption in cities, but the open road lets the engine operate more efficiently. The 4matic all-wheel drive system adds some weight and complexity, which slightly reduces fuel economy compared to a rear-wheel drive version. However, it provides better traction and stability in different weather conditions.

Annual fuel cost

The EPA estimates the annual fuel cost for the 2022 Mercedes-Benz E450 4matic Coupe is $2,400. This is based on driving 15,000 miles per year with a mix of city and highway driving, using the national average fuel price when the EPA tested it. Your fuel costs will vary based on your driving habits, local fuel prices, and miles driven. The $2,400 gives you a benchmark to compare the E450 Coupe to other vehicles in its class. Buyers should include this amount in their annual ownership costs.

Real-world expectations

The EPA estimates are a guideline, but don’t always match real-world driving. Aggressive driving, short trips, and idling can hurt fuel efficiency. Using a lighter touch on the gas and optimizing highway driving could improve these numbers. Owners say the 30 MPG highway figure is possible, especially on longer trips. City driving numbers will change based on traffic and driving style. Someone who enjoys the E450’s performance might see lower numbers, while a relaxed driver can likely meet or exceed the EPA estimates. If you’re interested in seeing E450 MPG across all years, resources like the EPA are available.

How it compares

Among luxury coupes, the E450 4matic Coupe’s fuel economy is average. The BMW 440i xDrive Coupe gets slightly better fuel economy, at 25 MPG combined. The Audi S5 Coupe, with its more potent V6, gets a bit less, at 24 MPG combined. The Lexus RC 350 AWD gets 22 MPG combined. This MPG difference might not be a big deal to someone buying an E450 Coupe. This car focuses on elegance, comfort, and a smooth driving experience more than fuel efficiency, and the potential savings from slightly better MPG probably won’t change the mind of someone buying a luxury vehicle. Prospective buyers can find all Mercedes Benz fuel economy data on FuelEconomyHub.

Tips to maximize efficiency

Use the E450 Coupe’s ECO driving mode. This changes throttle response and shift points to focus on fuel efficiency, without hurting performance too much. It’s an easy way to improve MPG in normal driving.

Make sure your tires are inflated properly. Underinflated tires increase rolling resistance, which wastes fuel. Check your tire pressure regularly and keep it at the recommended levels, which you can find on the driver’s side doorjamb or in the owner’s manual.

Avoid idling too much. Modern engines are efficient, and idling wastes fuel. If you’re going to wait more than a minute or two, turn off the engine.

Use smooth acceleration. Fast acceleration and hard braking use more fuel than gradual inputs. Watch traffic and keep a consistent speed when you can.