25 MPG combined isn’t a headline figure, but for the 2022 Mercedes-Benz E450 4matic, it’s an acceptable trade-off. This car is bought for its understated elegance and its turbocharged engine with electric motor, and effortless performance, not for its ability to sip fuel . Buyers prioritize the E450’s smooth, powerful inline-six engine and luxurious interior over achieving Prius-like fuel economy.

City and highway performance

The EPA estimates the E450 4matic will achieve 23 MPG in city driving and 30 MPG on the highway. The city figure reflects stop-and-go traffic, and the engine’s start/stop system helps nudge the number higher. On the open road, the E450 truly shines. Its 3.0L turbocharged engine, paired with a smooth 9-speed automatic transmission, provides effortless cruising power, allowing the car to maintain speed with minimal effort. The aerodynamic profile of the E-Class also plays a role in achieving that highway fuel economy rating.

Annual fuel cost

According to the EPA, the estimated annual fuel cost for the 2022 Mercedes-Benz E450 4matic is $2,300. This figure is based on driving 15,000 miles per year and using national average fuel prices. Your actual fuel costs will vary depending on your driving habits, local fuel prices, and the type of driving you do, but the $2,300 figure provides a baseline for comparison. This estimate may influence buyers who are concerned about fuel efficiency while balancing their desire for luxury and performance.

Real-world expectations

While the EPA estimates provide a useful benchmark, real-world fuel economy often differs. The E450 4matic’s turbocharged engine can be sensitive to driving style. More aggressive acceleration and frequent bursts of speed will lead to lower MPG. And, the use of features like the climate control system and heated seats can have a minor impact on fuel consumption. With a conscious effort to drive smoothly and anticipate traffic conditions, it’s possible to come close to the EPA’s estimates for both city and highway driving.

How it compares

The E450’s fuel economy sits in a competitive position within its class, but it’s not class-leading. For example, the BMW 540i xDrive, another inline-six-powered luxury sedan, achieves a similar 25 MPG combined. The Audi A6 55 TFSI, with its supercharged V6, also posts figures in the same ballpark. If fuel economy is a top priority, buyers might consider the Lexus ES 350, which uses a naturally aspirated V6 and achieves around 26 MPG combined in FWD guise. Drivers should view E450 MPG across all years before making a purchasing.

Tips to maximize efficiency

Use the E450’s “Eco” driving mode. This mode adjusts the throttle response, transmission mapping, and climate control settings to prioritize fuel efficiency. While it might slightly reduce the car’s responsiveness, it can make a noticeable difference in fuel consumption, especially during city driving.

Ensure your tires are properly inflated to the recommended pressure. Underinflated tires increase rolling resistance, which can significantly reduce fuel economy. Check your tire pressure regularly, especially during changes in temperature.

Avoid unnecessary idling. If you’re stopped for more than a minute, turn off the engine. The E450’s start/stop system can help with this in many situations, but manually shutting off the engine is even more effective.

Minimize aerodynamic drag by removing any roof racks or cargo carriers when not in use, as they can increase wind resistance. Even small changes to the car’s aerodynamics can impact fuel economy, particularly at higher speeds.

Consider using cruise control on the highway. Maintaining a consistent speed helps to optimize fuel efficiency. Avoid accelerating and decelerating unnecessarily, as this wastes fuel. While adaptive cruise control is helpful, be mindful of its tendency to brake and accelerate abruptly, which can impact fuel economy.

The E450 4matic is more than just a way to save gas; it has sophisticated style and performance. Shoppers can view all Mercedes Benz fuel economy data to compare models.