22 MPG combined won’t top any fuel-sipping lists, but for the 2019 Mercedes-Benz E450 4matic Coupe, it’s almost beside the point. This car is designed for a specific buyer: someone who prioritizes style, comfort, and a touch of performance over frugality. They want a sleek, head-turning coupe with a luxurious interior and the sure-footedness of all-wheel drive, and they are willing to pay for it, at the dealership and at the pump.

City and highway performance

The EPA estimates the E450 4matic Coupe at 19 MPG in the city and 26 MPG on the highway. The city figure reflects stop-and-go traffic where the turbocharged 3.0L inline-six requires more fuel to get its heft moving from a standstill. The highway number is more respectable and is aided by the smooth-shifting nine-speed automatic transmission, which allows the engine to cruise at lower RPMs, minimizing fuel consumption once you’re up to speed. However, keep in mind that this car begs to be driven with verve, and a heavy foot will inevitably drag those figures down.

Annual fuel cost

According to the EPA, the annual fuel cost for the 2019 Mercedes-Benz E450 4matic Coupe is approximately $2,650. This calculation is based on driving 15,000 miles per year and using national average fuel prices. Given that premium fuel is recommended (or even required in some markets), that figure could easily be higher depending on current prices in your region and your individual driving habits. It’s a substantial sum, but prospective E450 owners are likely prepared for it.

Real-world expectations

While the EPA figures provide a useful baseline, real-world MPG can vary significantly based on driving style, traffic conditions, and even the terrain you frequently encounter. Owners who regularly engage the car’s sportier driving modes or live in hilly areas will likely see lower numbers than those who primarily cruise on flat highways. Expect to see figures in the high teens around town, and potentially crack 30 MPG on longer highway journeys if you drive with a light foot. But realistically, most drivers will probably average around 20-24 MPG in mixed driving a bit below the EPA’s combined rating.

How it compares

The fuel economy of the E450 4matic Coupe is less competitive than some of its rivals. For instance the BMW 440i xDrive Coupe achieves 25 MPG combined. The Audi S5 Coupe, with its turbocharged V6, is rated at 24 MPG combined. Even similar offerings from within the Mercedes-Benz lineup, like some versions of the C-Class Coupe, can achieve slightly better figures. However, buyers interested in E450 MPG across all years are buying a car for many reasons, and the combined fuel economy ratings rarely make or break the deal.

Tips to maximize efficiency

Take advantage of the car’s driving modes. The “Comfort” setting prioritizes fuel efficiency by modulating throttle response and shift points. Selecting this mode in everyday driving will allow the car to shift as quickly as possible and remain in the highest gear to conserve fuel. For those concerned about fuel economy, leaving the car in the “Sport” or “Sport+” modes, while potentially rewarding with quicker acceleration, will definitely have a negative impact.

Maintain proper tire inflation. Underinflated tires increase rolling resistance, forcing the engine to work harder and consuming more fuel. Check your tire pressures regularly and inflate them to the manufacturer’s recommended levels, which can be found on a sticker inside the driver’s side door jamb. This is one of the simplest ways to reduce fuel consumption without sacrificing performance or comfort.

Avoid aggressive driving. Rapid acceleration and hard braking burn significantly more fuel than smooth, gradual inputs. Anticipating traffic flow and maintaining consistent speeds can dramatically improve your MPG. Enjoy the E450’s impressive performance when appropriate, but practice restraint when commuting or on routine errands.

Minimize idling. Idling consumes fuel without covering any distance. If you anticipate being stopped for more than a minute, turn off the engine. Modern cars like the E450 4matic Coupe are designed to restart quickly and reliably, so don’t hesitate to use this technique. While not applicable in certain climate control situations, avoiding unnecessary idle time will yield a fuel savings over time.

Keep up with scheduled maintenance. A well-maintained engine runs more efficiently. Follow the manufacturer’s recommended maintenance schedule, including regular oil changes, air filter replacements, and spark plug inspections. These relatively minor services can have a noticeable impact on your car’s fuel economy and overall performance. Be sure to check all Mercedes Benz fuel economy data when making decisions like these.