The 2019 Mercedes-Benz E450 4Matic’s 23 MPG combined won’t be winning any awards for efficiency, nor is it designed to. This mid-size luxury sedan prioritizes effortless cruising and confident performance, and its fuel consumption reflects that. The E450 buyer likely prioritizes the refined power and all-weather security over ultimate fuel savings.

City and highway performance

The EPA estimates the E450 4Matic at 20 MPG in the city and 28 MPG on the highway. The city number reflects the frequent stops and starts of urban driving, where the engine idles more and accelerates from a standstill often. The highway figure is where the E450 shines. The 9-speed automatic transmission allows the engine to cruise at low RPMs, maximizing efficiency on long journeys. While 28 MPG might seem modest, this is achieved with a turbocharged 3.0L inline-6, providing ample power for passing and merging.

Annual fuel cost

The EPA estimates the annual fuel cost for the 2019 Mercedes-Benz E450 4Matic at $2,500. This figure is based on driving 15,000 miles per year and using national average fuel prices. Your actual fuel costs may vary depending on your driving habits, location, and fuel prices. The E450 requires premium fuel, which will increase the operating cost compared to vehicles that run on regular gasoline.

Real-world expectations

EPA estimates provide a baseline, but real-world fuel economy can differ. Aggressive driving, frequent short trips, and carrying heavy loads can all negatively impact fuel consumption. Consistent maintenance and optimized driving can improve mileage beyond the EPA estimates. Expect numbers close to the EPA ratings with conservative driving, proper vehicle maintenance, and primarily long-distance highway travel. However, aggressive acceleration and mostly city traffic will likely result in fuel economy closer to the city rating of 20 MPG, or even lower. Many factors affect fuel economy so your personal experience will vary.

How it compares

Compared to its rivals, the 2019 Mercedes-Benz E450 4Matic’s fuel economy is normal for its class. The BMW 540i xDrive, with a similar 3.0L turbocharged inline-6, achieves an EPA-estimated 25 MPG combined. The Audi A6 3.0T Quattro delivers around 24 MPG combined. These numbers highlight that the three German manufacturers prioritize performance, which impacts fuel consumption. The Lexus ES 350 (with front-wheel drive and a V6 engine) achieves a combined 26 MPG for buyers who want more fuel economy, but it comes at the expense of sporty handling and all-wheel drive. Before buying, cross-shop these vehicles and consider your needs and preferences. You can also view E450 MPG across all years to learn more.

Tips to maximize efficiency

The E450’s turbocharged engine benefits from smooth acceleration. Avoid pressing the accelerator hard especially from a standstill, as this burns extra fuel without improving acceleration much. Maintain a steady speed and anticipate traffic to minimize unnecessary braking and acceleration.

Ensure your tires are inflated to the recommended pressure listed on the door jamb. Underinflated tires increase rolling resistance, reducing fuel efficiency. Regularly check your tire pressure and adjust as needed, especially during temperature changes. Even a small difference can lead to wasted fuel and increased tire wear.

Use the E450’s selectable drive modes. The “Comfort” or “Eco” modes optimize the engine and transmission for fuel efficiency. The transmission may shift earlier, and the throttle response might become less sensitive, encouraging fuel-efficient driving. Avoid “Sport” or “Sport+” modes for daily commuting if saving fuel is a priority.

Reduce weight in the vehicle. Extra cargo increases the energy needed to accelerate and maintain speed. Remove any non-essential items, especially heavy or bulky objects, to improve fuel economy. A cluttered trunk can have a noticeable impact, especially in city driving.

Schedule regular maintenance. A well-maintained engine runs more efficiently. Ensure the spark plugs, air filter, and other components are replaced according to the manufacturer’s intervals. Regular oil changes with the correct synthetic oil are also important for engine performance and fuel economy. Explore all Mercedes Benz fuel economy data to help with your research.