25 MPG combined is a reasonable figure for the 2024 Mercedes-Benz E450 4matic, a car that prioritizes a smooth and refined driving experience and effortlessly delivered power over significant fuel savings. While this number isn’t the highest in fuel efficiency, it reflects the car’s turbocharged six-cylinder engine with standard all-wheel drive, and the luxurious features expected of an E-Class.

City and highway performance

The E450’s EPA ratings break down to 22 MPG in the city and 31 MPG on the highway. The city figure reflects the reality of stop-and-go traffic, where the engine’s mild-hybrid system offers some assistance during acceleration. However, the engine’s displacement and the vehicle’s weight affect fuel economy. The highway number is more favorable, showing the engine’s efficiency at steady speeds and the effectiveness of the nine-speed automatic transmission in keeping the engine at its optimal rev range. Drivers who spend more time on open roads will naturally see fuel bills lower than those who drive mostly in urban environments.

Annual fuel cost

The EPA estimates the annual fuel cost for the 2024 Mercedes-Benz E450 4matic at $2,300. This figure is based on driving 15,000 miles per year and using national average fuel prices. Keep in mind that premium fuel is recommended for the E450 to achieve its optimal performance and efficiency, and this will affect the annual cost. This number provides a clear benchmark for prospective buyers as they consider the overall cost of ownership.

Real-world expectations

While EPA estimates provide a useful baseline, real-world fuel economy often varies depending on driving habits, traffic conditions, and terrain. Expect the E450 to deliver figures close to the EPA estimates if driven conservatively. However, using the car’s power frequently will naturally result in lower MPG. The E450 encourages a spirited driving style, so buyers should be aware of the potential impact on fuel consumption. Many drivers report figures that fall slightly below the combined EPA rating, which is typical for vehicles in this class. Always compare these figures with E450 MPG across all years.

How it compares

The E450’s fuel economy sits roughly in the middle of its competitive set. The BMW 540i xDrive, another six-cylinder, all-wheel-drive luxury sedan, achieves a similar 25 MPG combined. The Audi A6 55 TFSI quattro also delivers around 24 MPG combined. Some competitors offer more fuel-efficient powertrains. For example, the Lexus ES 350, with its V6 engine and front-wheel drive, boasts a higher 26 MPG combined, but offers less performance and all-weather capability than the E450. The Volvo S90 B6 AWD, with its turbocharged and supercharged four-cylinder, achieves around 26 MPG combined as well. These differences matter to buyers balancing fuel efficiency with overall driving experience and desired features. For a quick overview of fuel efficiency across the brand visit all Mercedes Benz fuel economy data.

Tips to maximize efficiency

Take advantage of the E450’s driving modes. Selecting “Eco” mode softens throttle response and optimizes transmission shift points for fuel efficiency. Although it might slightly dampen the car’s responsiveness, it can lead to noticeable savings, especially during city driving.

Ensure your tires are properly inflated. Underinflated tires increase rolling resistance, which negatively impacts fuel economy. Check your tire pressure regularly and maintain it at the recommended level found on the door jamb sticker.

Anticipate traffic flow and avoid unnecessary acceleration and braking. Smooth, consistent driving is key to maximizing fuel economy. Using cruise control on the highway can also help maintain a steady speed and reduce fuel consumption.

Reduce unnecessary weight in the vehicle. Carrying around extra cargo adds to the vehicle’s load and reduces fuel efficiency. Remove any items you don’t need to lighten the load and improve MPG.

Minimize idling time. If you’re stopped for more than a minute, it’s more fuel-efficient to turn off the engine than to let it idle. The E450’s mild-hybrid system is designed to restart the engine smoothly and quickly, so feel free to use it.