The 2021 Mercedes-Benz E450 4matic, equipped with its smooth and potent 3.0L inline-six, achieves a combined fuel economy of 26 MPG. That figure isn’t going to win any green awards, but it lands where you’d expect for a luxury sedan prioritizing performance and a certain kind of driving experience. E450 buyers aren’t primarily motivated by fuel efficiency; they prioritize a blend of refinement, power, and technological innovation. They understand the trade-offs in a car that delivers effortlessly strong acceleration and comfort.

City and highway performance

The EPA estimates suggest 23 MPG in the city and 30 MPG on the highway for the E450 4matic. The city estimate reflects the stop-and-go nature of urban driving, where the engine’s start-stop system works to conserve fuel during brief halts. The 30 MPG highway figure is indicative of the car’s relaxed cruising ability, thanks to the nine-speed automatic transmission which keeps the engine humming at low RPMs. The E450’s inherent smoothness and abundant torque mean it never feels strained, even when accelerating to pass at highway speeds. This helps contribute to reasonable economy on long trips.

Annual fuel cost

The EPA estimates the annual fuel cost for the 2021 Mercedes-Benz E450 4matic at $2,250. This figure is based on driving 15,000 miles per year and assumes current national average fuel prices. It’s a useful benchmark for comparing running costs against other vehicles, but your personal fuel expenses will fluctuate depending on your individual driving habits, the type of fuel you use, and prevailing gas prices in your area.

Real-world expectations

While the EPA figures provide a standardized benchmark, real-world fuel economy for the E450 4matic will vary based on driving style, traffic conditions, and even the specific terrain you typically encounter. Aggressive acceleration, frequent short trips, and consistent use of Sport or Sport+ driving modes will reduce fuel economy. On the other hand, smooth acceleration, anticipating traffic flow, and using the Eco driving mode can help you achieve numbers closer to, or even slightly exceeding, the EPA estimates. Understanding how your driving habits impact fuel consumption is key to optimizing efficiency in your E450. Drivers looking for more details can review E450 MPG across all years to see how the model has changed over time.

How it compares

The E450’s fuel economy is competitive within its class, but other options exist for buyers prioritizing efficiency. The BMW 540i xDrive achieves a similar 25 MPG combined with its inline-six engine. The Audi A6 55 TFSI, with its comparable six-cylinder engine, also delivers around 25 MPG combined. The Lexus ES 350, while not directly comparable in terms of performance and driving dynamics, offers significantly better fuel economy at 26 MPG combined with its V6 engine, but lacks the prestige and performance of the German trio. For buyers prioritizing less gas, Mercedes-Benz also offers plug-in hybrid variants of the E-Class, such as the E350e, which provide superior fuel economy and limited electric driving range. Reviewing all Mercedes Benz fuel economy data can help give you a broad look at the brand.

Tips to maximize efficiency

Use the Eco driving mode, especially in city traffic. This mode optimizes the engine and transmission settings for maximum fuel efficiency, often softening throttle response and initiating earlier upshifts. It’s a simple yet effective way to reduce fuel consumption without sacrificing comfort.

Monitor your tire pressure regularly. Underinflated tires increase rolling resistance, forcing the engine to work harder and consume more fuel. Refer to the sticker inside the driver’s side doorjamb for the recommended tire pressure and ensure your tires are properly inflated.

Resist the urge for aggressive acceleration. The E450’s engine is responsive and eager, but heavy acceleration significantly impacts fuel economy. Smooth, progressive acceleration is much more efficient and still allows you to fully enjoy the car’s performance capabilities when needed.

Reduce unnecessary weight. Extra cargo in the trunk or passenger compartment adds weight, increasing the amount of energy required to move the vehicle. Remove any items you don’t need on a regular basis to minimize fuel consumption.

Consider the type of fuel you use. While the E450 is designed to run on premium gasoline, using lower octane fuel can negatively impact performance and potentially fuel economy. Sticking to the manufacturer’s recommendation will ensure optimal engine efficiency and longevity.