The 2020 Mercedes-Benz E450 4matic, with its 23 MPG combined rating, occupies a unique position. It’s not trying to be the most efficient car, but it’s a luxury mid-size sedan, or wagon, that prioritizes performance, comfort, and presence. The E450 4matic buyer isn’t overly concerned with maximizing fuel efficiency. They want a smooth, powerful driving experience, a well-crafted interior, and the prestige of the Mercedes-Benz brand. This fuel economy is simply a byproduct.

City and highway performance

The EPA estimates of 20 MPG in the city and 28 MPG on the highway accurately reflect the E450 4matic’s capabilities. In urban environments, the 3.0L turbocharged inline-six engine delivers easy acceleration, providing 362 horsepower and 369 lb-ft of torque. This strong performance and the standard 4matic all-wheel drive contribute to the lower city MPG. The E450 4matic excels on the open road. The nine-speed automatic transmission shifts smoothly, keeping the engine at optimal efficiency. At cruising speeds, the E450 feels relaxed, easily achieving or exceeding the 28 MPG highway estimate, especially on long, flat roads.

Annual fuel cost

The EPA estimates the annual fuel cost for the 2020 Mercedes-Benz E450 4matic at $2,500. This is based on driving 15,000 miles per year, with 45% in the city and 55% on the highway. The calculation also reflects the national average fuel price, which varies by location and time of year. Given that the E450 4matic requires premium fuel, this represents a significant expense. However, buyers generally consider this an acceptable cost of ownership for this vehicle class. For more information, see E450 MPG across all years.

Real-world expectations

While the EPA estimates are useful, real-world fuel economy varies depending on driving style, traffic, and terrain. Aggressive acceleration, frequent hard braking, and long idling times negatively affect fuel efficiency. A smooth, steady driving style, combined with careful route planning, helps drivers achieve or exceed the EPA estimates. Owners report that, in mixed driving, achieving a combined MPG in the low 20s is realistic. Those driving mainly on the highway often see figures near the EPA’s 28 MPG rating. Tire pressure, vehicle maintenance, and accessories like air conditioning also affect overall fuel economy.

How it compares

The 2020 Mercedes-Benz E450 4matic’s fuel economy is similar to its competitors. The BMW 540i xDrive, with its 3.0L turbocharged inline-six, blends performance and fuel efficiency, achieving an EPA-estimated 22 MPG combined. The Audi A6 55 TFSI quattro achieves around 24 MPG combined with its turbocharged V6, another alternative. The Lexus GS 350 AWD, known for reliability, achieves 22 MPG combined, a bit lower. These minor differences often are less important than styling, features, brand prestige, and driving dynamics. Better understanding all Mercedes Benz fuel economy data can help you compare to other models.

Tips to maximize efficiency

Avoid aggressive acceleration and braking. The E450 4matic’s powerful engine is responsive, and consistently flooring it will drain the fuel tank. Focus on smooth acceleration and anticipate traffic to avoid braking.

Use the car’s driving modes. The E450 4matic typically offers Eco, Comfort, and Sport driving modes. Eco mode optimizes engine and transmission settings for maximum fuel efficiency, while Comfort provides a balanced driving experience. Sport mode prioritizes performance, so using it sparingly helps conserve fuel.

Maintain proper tire inflation. Underinflated tires increase rolling resistance, negatively impacting fuel economy. Check tire pressure regularly and inflate tires to the manufacturer’s recommended levels, found on the doorjamb or in the owner’s manual.

Minimize idling. Idling consumes fuel without covering distance. If you expect to be stopped for more than a minute or two, turn off the engine. This practice can add up to fuel savings.