27 MPG combined for the 2025 Mercedes-Benz CLE300 4MATIC Coupe makes it an efficient luxury two-door. This vehicle provides performance, refinement, and genuine all-weather usability. This isn’t just an impressive number on paper, it reflects modern powertrain technology. The CLE300 4MATIC is for the individual who values effortless cruising, impeccable style, and a sense of occasion, yet understands that cutting-edge efficiency does not detract from the premium experience. This vehicle delivers power with remarkable parsimony, blending exhilarating drives with sensible running costs.

City and highway performance

The EPA rates the 2025 CLE300 4MATIC Coupe at 24 MPG in the city and 33 MPG on the highway. These figures show a powertrain optimized for varying driving conditions in a luxury coupe with standard all-wheel drive. The 2.0-liter turbocharged four-cylinder engine, paired with the 9-speed automatic transmission, works to maximize efficiency without compromising the refined power delivery expected from a Mercedes-Benz. City driving, often a fuel economy killer for many vehicles, benefits from the engine’s strong low-end torque and the transmission’s quick, intelligent shifts, keeping the engine in its most efficient operating range. On the open road, the 9-speed unit allows for exceptionally low cruising RPMs, extracting maximum mileage from every drop of premium fuel. For those considering the CLE300 4MATIC, these numbers reveal a vehicle engineered to perform effectively and efficiently, whether navigating urban traffic or covering vast distances on the interstate. Exploring CLE300 MPG across all years reveals a consistent commitment to this balance.

Annual fuel cost

The EPA estimates an annual fuel cost of $2,150 for the 2025 Mercedes-Benz CLE300 4MATIC Coupe. This figure is based on driving 15,000 miles per year, split evenly between city and highway conditions, using national average fuel prices for premium gasoline. For the target demographic of the CLE300 4MATIC, this represents a highly manageable and excellent expenditure for a luxury coupe. It shows Mercedes-Benz’s ability to deliver premium experiences without excessive operational burdens. The annual fuel cost calculation provides a tangible benchmark, confirming that the vehicle’s advanced powertrain technology translates directly into tangible savings over the course of a year, contributing to the overall value of this two-door.

Real-world expectations

In real-world driving, owners of the 2025 CLE300 4MATIC Coupe can expect to achieve or even slightly exceed the EPA estimates, particularly those with a conscientious driving style. Mercedes-Benz powertrains are well-calibrated, and the 2.0L turbo-four is a prime example of their engineering efficiency. The 9-speed automatic is a masterclass in smooth, imperceptible gear changes, always seeking the optimal ratio for fuel conservation without feeling sluggish. Aggressive driving, frequent hard acceleration, and consistent high speeds will naturally see figures dip closer to the city rating, even on highway stretches. Conversely, disciplined drivers who use the car’s ECO drive mode and maintain moderate speeds will find the 33 MPG highway rating quite attainable, making long road trips a surprisingly economical affair in this luxurious coupe. The vehicle’s character encourages smooth and refined driving, which inherently supports better fuel economy.

How it compares

The 2025 Mercedes-Benz CLE300 4MATIC Coupe’s 27 MPG combined places it competitively, and in some cases, ahead of its direct rivals in the luxury coupe segment. For instance, the Audi A5 Coupe 45 TFSI quattro, a natural competitor, typically registers around 27 MPG combined (24 city/32 highway). BMW’s 430i xDrive Coupe, another key player, also hovers around 27 MPG combined (24 city/34 highway), indicating that Mercedes-Benz has matched the segment efficiency benchmark. The Lexus RC 300 AWD, while offering a similar luxury experience, uses a V6 engine and usually sees combined figures closer to 23 MPG. Buyers of the CLE300 4MATIC are cross-shopping these very vehicles, and the Mercedes-Benz’s equivalent or superior fuel economy, particularly with its powerful yet refined 2.0L engine, strengthens its position. For specific data on all Mercedes-Benz fuel economy, the context becomes even clearer.

Tips to maximize efficiency

Use the CLE300’s ECO drive mode whenever conditions allow. This mode optimizes throttle response, transmission shift points, and climate control, subtly recalibrating the car’s systems for maximum fuel conservation without requiring conscious effort from the driver.

Maintain consistent highway speeds using the adaptive cruise control. This system expertly manages acceleration and deceleration, avoiding unnecessary bursts of power and braking that consume extra fuel, especially in moderate traffic.

Check tire pressure regularly, at least once a month. Underinflated tires increase rolling resistance, forcing the engine to work harder and directly impacting fuel economy. The CLE300’s tire pressure monitoring system provides a convenient reminder for this critical maintenance item.

Practice smooth acceleration and anticipate traffic flow. Gentle throttle inputs and coasting to stops, rather than abrupt braking, significantly reduce fuel consumption, especially in urban environments where the 2.0L engine’s efficiency benefits greatly from a light foot.

Minimize idling time. The CLE300’s automatic start/stop system is designed to shut off the engine at stops, but for longer waits, manually shutting off the engine can further conserve fuel and reduce emissions.