16 MPG combined for the 2025 Mercedes-AMG GLE63 S 4MATIC+ Coupe delivers exhilarating performance and opulent luxury, with fuel economy taking a back seat. This isn’t a vehicle for those focused on mileage, but rather for those who prioritize a ferocious V8 soundtrack, relentless acceleration, and an uncanny ability to dominate any road, regardless of the cost at the pump. The buyer of this AMG understands they are acquiring a magnificent machine designed to thrill, not to sip fuel, and they embrace that truth without reservation.

City and highway performance

Looking at the EPA figures, the 2025 AMG GLE63 S 4MATIC+ Coupe is rated at 14 MPG in the city and 19 MPG on the highway. These numbers are entirely predictable for a vehicle packing a twin-turbocharged 4.0L V8 engine, generating over 600 horsepower, and weighing more than 5,000 pounds. In urban environments, where the engine’s power is eagerly used from stoplight to stoplight, and during frequent low-speed maneuvering, consumption naturally climbs. The 9-speed automatic transmission, while brilliant in its responsiveness and smoothness, can only do so much to mitigate the thirst of eight cylinders eager to rev. On the open highway, however, that 19 MPG figure is, frankly, impressive for such a high-performance SUV. Maintaining a steady pace allows the powertrain to truly stretch its legs, settling into higher gears and benefiting from the inherent efficiency of cruising. Of course, maintaining that “steady pace” in an AMG is often easier said than done, as the tempting swell of torque and the intoxicating engine note routinely encourage a more spirited driving style, which will inevitably dip those highway figures into the lower teens.

Annual fuel cost

The EPA estimates an annual fuel cost of $3,600 for the 2025 Mercedes-AMG GLE63 S 4MATIC+ Coupe. This figure is based on driving 15,000 miles per year, with 45% of that mileage in city conditions and 55% on the highway, using national average fuel prices, and assuming the use of premium unleaded gasoline, as recommended for this high-compression, high-performance engine. For the typical AMG buyer, this annual fuel outlay is simply factored into the cost of ownership, alongside insurance, maintenance, and depreciation. It is a necessary expense for enjoying the unrivaled performance and prestige of this vehicle. A prospective owner expecting Prius-level economy is looking at the wrong vehicle altogether, and frankly, doesn’t understand the fundamental appeal of an AMG. The $3,600 is not a deterrent, it’s a receipt for exhilaration.

Real-world expectations

In the real world, achieving the stated 16 MPG combined with the AMG GLE63 S 4MATIC+ Coupe requires a degree of restraint that many owners simply won’t exercise. This vehicle begs to be driven hard. Its power delivery is instantaneous, the exhaust note addictive, and the handling surprisingly agile for its size. Consequently, owners who routinely tap into the engine’s prodigious power will likely see their combined MPG dip closer to 12-14 MPG. Conversely, those disciplined enough to engage the ECO drive mode, anticipate traffic, and avoid abrupt acceleration and braking, might occasionally nudge closer to the 16 MPG combined figure. However, the true mission of this vehicle is not about efficiency, it’s about the visceral connection between driver and machine, about the thrill of performance. Real-world fuel economy for an AMG, especially one with a 4.0L V8, is overwhelmingly dictated by the driver’s lead foot. This is a known quantity for buyers in this segment, and they accept it. For more detailed information on all Mercedes Benz fuel economy data, our site has extensive records.

How it compares

The 2025 Mercedes-AMG GLE63 S 4MATIC+ Coupe exists in an exclusive club, competing against other high-performance luxury SUVs. Let’s look at how it stacks up against its closest rivals in terms of fuel economy. The BMW X6 M Competition, for instance, typically returns a combined 15 MPG (13 City / 18 Highway) from its twin-turbo 4.4L V8, putting it neck and neck with the AMG. The Porsche Cayenne Turbo E-Hybrid, a plug-in hybrid, offers a significantly higher combined 46 MPGe, but its gasoline-only combined figure is often around 19 MPG, though its mission is distinctly different. The Audi RS Q8, with its 4.0L twin-turbo V8, usually rings in at 16 MPG combined (15 City / 20 Highway), again virtually identical to the AMG. Even the Lamborghini Urus, arguably one step further up the performance ladder, manages only 14 MPG combined (12 City / 17 Highway). What these comparisons reveal is that the AMG GLE63 S 4MATIC+ Coupe’s 16 MPG combined is right in line with, or even slightly better than, its direct, non-hybridized, ultra-performance SUV competitors. For those interested in how these figures change over time, our AMG MPG across all years page offers a historical view.

Tips to maximize efficiency

While the AMG GLE63 S 4MATIC+ Coupe isn’t designed for fuel economy, there are still strategies to mitigate its thirst slightly. Using the ECO drive mode whenever performance isn’t important will significantly soften throttle response and optimize transmission shift points, helping to conserve fuel. This mode also often engages cylinder deactivation more frequently, temporarily turning your V8 into a V4 under light load conditions.

Regularly checking and maintaining proper tire pressure is a simple yet effective way to improve fuel economy. Under-inflated tires increase rolling resistance, forcing the engine to work harder. The AMG’s large performance tires are especially sensitive to pressure variations, impacting both handling and efficiency.

Anticipating traffic flow and driving smoothly, avoiding aggressive acceleration and hard braking, will contribute more to fuel savings than almost any other technique. The kinetic energy lost during braking is energy that the engine had to expend to accelerate the vehicle, and smooth driving minimizes these losses.

Minimizing unnecessary weight in the vehicle can also have a small but measurable impact on efficiency. While the massive V8 is the primary factor, shedding excess cargo lightens the load and marginally reduces the effort required to propel the vehicle down the road.

Finally, adhering to the manufacturer’s recommended service schedule ensures the engine, transmission, and all other systems are operating at peak efficiency. Fresh oil, clean air filters, and properly functioning spark plugs all contribute to the engine performing as intended, avoiding any undue fuel consumption from maintenance neglect.