24 MPG combined in the 2024 Mercedes-Benz S500 4matic 3.0L 6-cyl isn’t going to win any fuel efficiency awards, but it’s also not the main purpose of this car. The target customer for a six-figure luxury sedan isn’t likely pinching pennies at the pump. This is a statement car, a mobile office, and a sanctuary of comfort, and its fuel consumption reflects the performance and technology in every detail.

City and highway performance

The EPA estimates the S500 4matic will achieve 21 MPG in the city and 31 MPG on the highway. The city figure reflects stop-and-go traffic where the engine is constantly working. The 3.0L inline-six, with mild-hybrid technology, still requires fuel to power the car’s mass and luxury features.

The highway figure, however, is more impressive. The nine-speed automatic transmission allows the engine to cruise at lower RPMs, and the aerodynamic design helps reduce drag, both contributing to better fuel economy. The difference between city and highway figures indicates that longer, uninterrupted drives are where the S500 4matic will be most efficient.

Annual fuel cost

According to the EPA, the annual fuel cost for the 2024 Mercedes-Benz S500 4matic is $2,400. This estimate is based on driving 15,000 miles per year and using national average fuel prices. Actual fuel costs will vary depending on individual driving habits, local fuel prices, and the type of fuel used. If you frequently drive aggressively or live in an area with high fuel costs, you can expect to pay more.

If you drive fewer miles, your overall fuel expenditure will be lower. Even with a higher final cost, the expected clientele for the S500 doesn’t choose the large luxury sedan category for its fuel efficiency at the expense of other factors.

Real-world expectations

While the EPA estimates provide a benchmark, real-world fuel economy can vary significantly. Factors such as driving style, traffic conditions, and even tire pressure can impact fuel consumption. It’s reasonable to expect that owners who prioritize comfort and performance over efficiency may see figures closer to the city estimate, especially during shorter trips.

However, those who frequently undertake long highway journeys and adopt a more relaxed driving style might achieve or even exceed the EPA’s highway estimate. Monitoring your fuel consumption over time and making adjustments to your driving habits can help you better align with the EPA estimates. See S500 MPG across all years to compare these figures.

How it compares

The 2024 BMW 740i, another benchmark in the luxury sedan segment, achieves an EPA-estimated 25 MPG combined, slightly better than the S500. The Audi A8, often cross-shopped with the S-Class, lands at 22 MPG combined. While these differences may seem small, they can add up over the course of a year.

However, the S500 competes on more than just fuel economy. Its supremely comfortable interior, cutting-edge technology, and iconic styling often outweigh minor differences in fuel consumption for buyers. This buyer is looking for a complete experience, not just the lowest possible fuel bill.

Tips to maximize efficiency

Take advantage of the S500’s driving modes. Selecting “Eco” mode will optimize the engine and transmission settings for maximum fuel efficiency. This includes earlier upshifts, reduced throttle response, and optimized climate control settings. While it might slightly reduce performance, it can noticeably improve gas mileage, especially in city driving.

Ensure your tires are properly inflated. Underinflated tires increase rolling resistance, forcing the engine to work harder and consume more fuel. Check your tire pressure regularly and inflate them to the recommended levels, which can be found on the sticker inside the driver’s side door jamb.

Avoid aggressive driving habits. Rapid acceleration and hard braking significantly reduce fuel economy. Smooth, gradual acceleration and anticipation of traffic flow will not only improve fuel efficiency, but also improve the overall driving experience for both driver and passengers.

Minimize idling. Idling consumes fuel without covering any distance. If you anticipate being stopped for more than a minute, such as at a long traffic light, consider turning off the engine. The S500’s start-stop system is designed to do this automatically, restarting the engine when you’re ready to go. While some drivers of older cars suggest not stop-start systems, the S500 is designed from the ground up to accommodate start-stop and is a part of its overall fuel consumption strategy.

Keep your vehicle well-maintained. Regular maintenance, including oil changes, air filter replacements, and spark plug replacements, ensures that your engine is running optimally and efficiently. Neglecting maintenance can lead to decreased performance and reduced fuel economy. For all Mercedes Benz fuel economy data, see here.