The 2023 Mercedes-Benz E350 4matic achieves 24 MPG combined fuel economy. It isn’t a sports car or a hybrid focused on ultimate efficiency. It’s a mid-size luxury sedan primarily designed for comfort, safety, and the level of performance expected from Mercedes-Benz. The E350 4matic appeals to buyers prioritizing a refined driving experience and confidence in all weather conditions over saving fuel. They accept adequate MPG in return for the prestige, technology, and meticulously crafted interior that the E-Class offers.

City and highway performance

The E350’s EPA ratings are 21 MPG in the city and 30 MPG on the highway. In the city, stop-and-go traffic requires the 2.0L turbocharged four-cylinder engine to work harder, consuming more fuel due to the car’s weight. However, the smooth-shifting 9-speed automatic transmission makes the most of the engine’s power. On the highway, the E350’s 30 MPG demonstrates its efficient cruising capability. The aerodynamic design and higher transmission gears allow the engine to run at lower RPMs, saving fuel. This difference reflects the typical driving patterns of E-Class owners, balancing daily commutes with longer trips.

Annual fuel cost

The EPA estimates the annual fuel cost for the 2023 Mercedes-Benz E350 4matic at $2,400. This is based on driving 15,000 miles per year, using the national average fuel price. This is a helpful guide, but individual costs will change depending on driving habits, local fuel prices, and the fuel grade. While the E350 doesn’t require premium gasoline, some owners might choose it, which will increase costs.

Real-world expectations

EPA estimates provide a standardized comparison, but actual fuel economy varies. Aggressive driving, frequent short trips, and heavy loads will decrease MPG. Conversely, gentle acceleration, consistent highway speeds, and regular maintenance can help drivers get close to or slightly exceed the EPA figures. Understanding your driving habits is important for setting realistic expectations.

If you primarily drive in congested cities, expect MPG closer to the city estimate. However, if you often take long highway trips, you might see results closer to 30 MPG.

How it compares

The E350’s fuel economy is average for the mid-size luxury sedan market. The BMW 530i, using its own turbocharged 2.0L four-cylinder, achieves a similar 25 MPG combined. The Audi A6 45 TFSI, a direct competitor, gets an similar EPA-estimated 26 MPG combined. The Volvo S90 B6, with its turbocharged and supercharged engine, also offers 26 MPG combined. These small MPG differences often matter less than styling, features, and brand preference in this segment. The Lexus ES 350, while different in driving feel, achieves a slightly better 26 MPG combined with its V6 engine, which attracts buyers focused on reliability.

For significantly better fuel economy in a Mercedes-Benz, explore all Mercedes Benz fuel economy data for other models or powertrains. Also, consider the E350 MPG across all years to see potential differences.

Tips to maximize efficiency

Gentle acceleration is key. The E350’s turbocharged engine provides plenty of torque at low RPMs. Avoid hard acceleration and gradually increase speed to minimize fuel use, especially in the city.

Keep proper tire pressure. Underinflated tires increase rolling resistance, making the engine work harder and decreasing fuel economy. Regularly check your tire pressure and maintain the recommended levels, found on the driver’s side doorjamb.

Use cruise control on the highway. Consistent speed helps optimize fuel efficiency. Avoid sudden speed changes, which waste fuel.

Reduce weight. Extra weight in the trunk or cabin decreases fuel economy. Remove unnecessary items to lighten the load and improve efficiency.

Select “Comfort” mode when possible. The E350 has driving modes that change throttle response and transmission behavior. “Comfort” mode offers a more relaxed driving experience and can improve fuel economy in normal driving.