19 MPG combined isn’t the main reason someone buys a 2022 Mercedes-Benz S580 4matic. This is a flagship, a rolling sanctuary of opulence and technology, powered by a twin-turbocharged V8 that prioritizes effortless thrust over saving money on gas. The S580 buyer isn’t worried about the price of premium fuel; they want to arrive in comfort and style, and are willing to pay for that.

City and highway performance

The EPA estimates the S580’s city fuel economy at 16 MPG, a figure that will likely be even lower in stop-and-go traffic. The weight of this sedan and the inherent inefficiencies of a large displacement engine affect mileage. However, the story improves on the open road, where the S580 achieves a respectable 25 MPG highway rating. The nine-speed automatic transmission plays an important role here, keeping the engine in its most efficient range when cruising. The highway number is much better, and accurately reflects the S580’s natural driving condition: easily covering miles on long interstate journeys.

Annual fuel cost

The EPA calculates the annual fuel cost for the 2022 Mercedes-Benz S580 4matic at $3,050. This figure is based on driving 15,000 miles per year, with a percentage of city versus highway miles, at the national average fuel price for premium gasoline. Of course, this number can vary depending on individual driving habits and fluctuations in fuel prices. Heavy-footed drivers in dense urban environments are likely to exceed this figure, while those who primarily use the S580 for highway cruising may see slightly lower costs.

Real-world expectations

While the EPA estimates provide a benchmark, real-world MPG for the S580 will vary. Expect the combined figure to hover around the stated 19 MPG in mixed driving, but be prepared for lower numbers in congested city environments. The weight of the vehicle, the powerful V8 engine, and the standard all-wheel drive system all contribute to fuel consumption. Drivers who prioritize smooth acceleration and use the available Eco driving mode may see some improvement, fuel efficiency is not the S580’s primary design goal. For a broader perspective, browse all all Mercedes Benz fuel economy data.

How it compares

Compared to its rivals, the S580 is in the middle of the pack when it comes to fuel economy. The BMW 750i xDrive, with its similar V8, achieves virtually identical EPA ratings. The Audi A8, depending on the engine configuration, can offer slightly better mileage, but sacrifices some performance. The Lexus LS 500, with its twin-turbo V6, boasts marginally better figures around 22 MPG combined. However, the differences are relatively small, and buyers in this segment are unlikely to base their decision solely on fuel economy. They are more concerned with luxury, technology, and performance. If you want better fuel efficiency, consider reviewing S580 MPG across all years for hybrid options.

Tips to maximize efficiency

While the S580 isn’t fuel-efficient, you can take steps to optimize its performance. Avoid aggressive acceleration and hard braking, as these actions significantly impact fuel consumption. The S580’s powerful engine provides ample power for smooth progress; using it carefully will help.

Engage the Eco driving mode, if equipped. This mode typically adjusts the throttle response and transmission shift points to prioritize fuel efficiency. While it may slightly reduce performance, it can make a difference in MPG, especially during city driving.

Ensure that your tires are properly inflated. Underinflated tires increase rolling resistance, which reduces fuel economy. Check your tire pressures regularly and maintain them at the recommended levels, typically found on a sticker inside the driver’s side door jamb.

Minimize idling. If you anticipate being stopped for more than a minute, turn off the engine. Excessive idling consumes fuel without providing any benefit. The S580’s advanced systems also consume a lot of power while idling, impacting fuel efficiency.

Keep the vehicle properly maintained. Regular maintenance, including oil changes, air filter replacements, and tune-ups, ensures that the engine is running efficiently. A well-maintained engine will always deliver better fuel economy than one that is neglected.