24 MPG combined isn’t going to win the Mercedes-Benz E350 4matic any fuel-sipping awards, but it’s acceptable for a mid-size luxury sedan with all-wheel drive. This car is designed for comfort, quietness, and effortless performance, and while efficiency is a consideration, it’s not the main focus for most buyers.

City and highway performance

The EPA estimates for the 2022 E350 4matic are 21 MPG in the city and 29 MPG on the highway. The city rating reflects stop-and-go traffic, where the 2.0L turbocharged four-cylinder works harder. The highway number is more impressive. The 9-speed automatic transmission allows the engine to cruise at relatively low RPMs, maximizing fuel economy during long journeys. This split will appeal to buyers who value a comfortable commute but also appreciate the efficiency of a modern drivetrain when covering longer distances. Buyers can also find detailed E350 MPG across all years.

Annual fuel cost

The EPA estimates the annual fuel cost for the 2022 Mercedes-Benz E350 4matic to be about $2,400. This is based on driving 15,000 miles per year, with a mix of city and highway driving that reflects the combined MPG rating. The calculation also uses the national average fuel price, which fluctuates, but gives a consistent baseline for comparison. $2,400 might seem like a significant amount, but remember that this is a luxury vehicle, and its owners are generally less price-sensitive to fuel costs compared to economy car buyers.

Real-world expectations

The EPA provides a standardized estimate, but individual fuel economy can change based on driving habits, traffic, and even weather. Drivers who accelerate quickly can expect lower numbers, especially in the city. But those who prioritize smooth acceleration, anticipate traffic, and use cruise control on the highway may see results closer to, or even above, the EPA estimates. Winter driving, with cold starts and increased electrical load, can hurt fuel economy for this turbocharged engine.

How it compares

The E350 4matic’s fuel economy is competitive within its class. For example, the BMW 530i xDrive, another popular all-wheel-drive luxury sedan, gets about 23 MPG combined. The Audi A6 45 TFSI quattro, with its comparable turbocharged four-cylinder, also gets around 24 MPG combined. The Lexus ES 350 doesn’t offer all-wheel drive standard, but a hybrid version (ES 300h) greatly improves fuel economy to around 44 MPG combined, sacrificing some driving feel. Buyers in this segment often weigh all-weather capability, driving dynamics, and brand prestige, and will accept some MPG tradeoff for their chosen features, and you can find all Mercedes Benz fuel economy data on our website.

Tips to maximize efficiency

Use the E350’s driving modes. The “Comfort” or “Eco” settings will soften throttle response and optimize transmission shifts for fuel efficiency. “Sport” mode provides sharper acceleration, but uses more gas.

Make sure your tires are properly inflated. Underinflated tires increase rolling resistance, forcing the engine to work harder and reducing fuel efficiency. Check your tire pressure regularly and keep it at the recommended level, which can be found on a sticker inside the driver’s side door.

Avoid unnecessary idling. Modern engines, including the E350’s turbocharged four-cylinder, are designed to be shut off rather than idled for extended periods. If you expect to wait for more than a minute, turn off the engine to save fuel.

Drive smoothly and anticipate traffic. Avoid hard acceleration and braking, as these consume significant amounts of fuel. By anticipating traffic flow and maintaining a consistent speed, you can use less gas.

You may want to consider using premium fuel, even though it’s not strictly required. The E350’s engine is designed to run on regular unleaded, but some drivers report slightly improved performance and fuel economy with premium fuel, though this may not offset the higher cost of the fuel.