25 MPG combined is acceptable for the 2022 Mercedes-Benz CLS450 4matic. The CLS is a stylish, four-door coupe that values style and driving pleasure over efficiency. It’s not a hybrid, and it isn’t for buyers focused on saving fuel. The CLS buyer wants a statement car with a luxury badge and accepts moderate fuel consumption.

City and highway performance

The EPA estimates for the CLS450 4matic are 22 MPG in the city and 30 MPG on the highway. The city figure reflects stop-and-go driving, where the 3.0L inline-six engine works harder and the mild-hybrid system’s benefits decrease. The 30 MPG highway figure represents steady-state cruising, where the engine operates more efficiently, and the nine-speed automatic transmission uses its higher gears. These figures are reasonable for a car of this size, weight, and performance. The CLS450’s engine produces 362 horsepower, making highway passing easy.

Annual fuel cost

The EPA estimates the annual fuel cost for the 2022 Mercedes-Benz CLS450 4matic at $2,300. This is based on driving 15,000 miles per year and using national average fuel prices. This figure lets prospective buyers compare the CLS450’s operating costs with other vehicles. Your actual fuel costs may vary based on your driving habits, local fuel prices, and driving conditions.

Real-world expectations

While the EPA estimates provide a baseline, real-world fuel economy differs. CLS450 owners may find their actual MPG figures slightly above or below the EPA estimates, depending on driving style, traffic, and roads they typically drive. Those who frequently drive in urban areas might see figures closer to the 22 MPG city estimate, while those who spend more time on the open highway could approach or exceed the 30 MPG highway estimate. Aggressive driving and frequent use of the car’s sport modes will also lower fuel economy. Owners can check FuelEconomyHub for user-submitted data on CLS450 MPG across all years.

How it compares

The CLS450 competes with luxury four-door coupes such as the Audi A7 and BMW 8 Series Gran Coupe. The Audi A7, in its 55 TFSI quattro configuration, achieves an EPA-estimated 22 MPG combined. The BMW 840i Gran Coupe, with its inline-six engine and all-wheel drive, manages around 25 MPG combined, similar to the CLS450. These competitors offer similar performance and luxury, but styling, features, and driving dynamics often influence buyers. Shoppers should also check all Mercedes Benz fuel economy data to see how other models compare. Buyers in this segment often care more about exterior styling, interior, and brand image than fuel economy.

Tips to maximize efficiency

The “Comfort” mode optimizes fuel economy by prioritizing smooth acceleration and earlier gear shifts. “Sport” mode prioritizes performance, which will reduce your mileage. Use the CLS450’s driving modes to manage fuel consumption.

Underinflated tires increase rolling resistance, forcing the engine to work harder. Check your tire pressures regularly and maintain the levels in the owner’s manual. Ensure your tires are properly inflated.

Idling burns fuel. If you anticipate being stopped for more than a minute or two, turn off the engine. Modern engines restart quickly.

Avoid abrupt acceleration and braking, because they waste fuel. Anticipate traffic flow and maintain a steady speed. Practice smooth and consistent driving habits.

Excess weight reduces fuel economy, especially during city driving. Remove any unnecessary items from the trunk or rear seats. Lighten the load.