The 2022 Lexus RX 350 AWD gets 22 MPG combined. This isn’t a groundbreaking number, and it certainly won’t win any hypermiling contests. For the target buyer of this mid-size luxury SUV, individuals and families prioritizing reliability, a plush ride, and a proven ownership experience, it’s a compromise many are willing to make. The RX 350 doesn’t promise groundbreaking efficiency, but it consistently delivers a smooth, comfortable, and composed driving experience, year after year.

City and highway performance

The EPA estimates for the RX 350 AWD break down to 19 MPG in the city and 26 MPG on the highway. The city figure reflects the stop-and-go nature of urban driving, where the 3.5L V6 engine works harder to accelerate the RX’s mass. The highway MPG is noticeably better, demonstrating the engine’s ability to cruise efficiently at constant speeds. Aggressive driving habits, especially frequent hard acceleration, will significantly impact both city and highway fuel economy. The automatic (S8) transmission does its best to keep the engine in its optimal range, but the driver’s behavior plays an important role.

Annual fuel cost

The EPA calculates that you’ll spend approximately $2,000 on fuel annually driving the 2022 Lexus RX 350 AWD. This figure is based on driving 15,000 miles per year, with a mix of city and highway driving, and using the national average fuel price at the time of calculation. How much you spend will vary depending on driving habits, local fuel prices, and the specific ratio of city to highway miles. Fluctuating gas prices can alter this figure significantly, either up or down, but $2,000 provides a reasonable benchmark for budgeting.

Real-world expectations

While the EPA estimates are a useful starting point, real-world fuel economy often deviates. Many RX 350 AWD owners report achieving figures close to the EPA estimates in mixed driving conditions. Expect lower numbers in predominantly city driving, especially during rush hour. Extended highway road trips, driven at consistent speeds, may yield slightly better than the EPA’s 26 MPG rating. Tire pressure, vehicle maintenance, and even the type of gasoline used can subtly influence fuel consumption.

How it compares

Compared to its competitors, the RX 350 AWD sits squarely in the middle of the pack. The Acura MDX (21 MPG combined) offers similar fuel economy with a slightly sportier driving experience. The Volvo XC60 B5 AWD (25 MPG combined) boasts a more efficient turbocharged and supercharged engine. The BMW X3 xDrive30i (24 MPG combined) prioritizes performance but manages slightly better fuel efficiency. Even within the Lexus family, you can compare all Lexus fuel economy data to see where the RX 350 falls. The RX 450h, the hybrid variant of RX MPG across all years, delivers significantly better fuel economy but at a higher initial price point. The RX 350 buyer often prioritizes Lexus’ legendary reliability and lower maintenance costs over outright fuel efficiency, making this trade-off acceptable.

Tips to maximize efficiency

Avoid aggressive acceleration and braking. The RX 350 responds well to smooth, deliberate inputs. Plan your routes to minimize stop-and-go traffic, especially during peak hours. Even slight changes in driving style can reduce fuel consumption over time.

Maintain proper tire inflation. Underinflated tires increase rolling resistance, forcing the engine to work harder and burn more fuel. Check your tire pressures regularly and inflate them to the recommended levels found on the driver’s side doorjamb.

Regular maintenance is important. Ensure all scheduled maintenance is performed on time, including oil changes, air filter replacements, and spark plug inspections. A well-maintained engine operates more efficiently.

Consider lighter wheels and tires when it’s time for replacement. Reducing unsprung weight can improve both fuel economy and handling. Consult with a trusted tire professional for appropriate recommendations.

Minimize excess weight in the vehicle. Carrying unnecessary cargo adds to the vehicle’s overall weight, reducing fuel efficiency. Remove any items you don’t need, especially heavy objects stored in the trunk or cargo area.