24 MPG combined is what you can expect for the 2022 Audi S5 Coupe. It’s a practical number that allows this stylish two-door to deliver strong performance and a rewarding driving experience. The S5 coupe isn’t about maximizing efficiency; it’s about blending sporting intentions with everyday usability, and its fuel economy reflects that balance.

City and highway performance

The S5’s EPA ratings are 21 MPG in the city and 30 MPG on the highway. The city figure is respectable for a vehicle producing 349 horsepower, considering stop-and-go traffic keeps the turbocharger working. The 30 MPG highway number is achievable on long, steady cruises, proving that the S5 can be a comfortable grand tourer. Audi’s quattro all-wheel drive system comes standard, ensuring consistent grip in all conditions, but it adds weight and complexity that affects fuel consumption. The eight-speed automatic transmission is well-matched to the engine’s power delivery, offering quick shifts and helping to optimize fuel economy during relaxed driving. Driven carefully, the S5 can meet, or even slightly exceed, its EPA estimates under ideal conditions.

Annual fuel cost

According to the EPA, the annual fuel cost for the 2022 Audi S5 Coupe is $2,400. This figure is calculated based on driving 15,000 miles per year, with 55% of those miles driven in the city and 45% on the highway. The calculation also uses the national average fuel price at the time of estimation, which changes. Premium fuel is recommended for optimal performance, and using it will likely push your actual annual fuel costs above this estimate, depending on your driving habits and local fuel prices.

Real-world expectations

The EPA provides a standardized benchmark, but real-world fuel economy for the S5 Coupe can vary based on driving style, traffic, and even weather. Aggressive acceleration and frequent use of “Dynamic” mode will lower MPG. However, prioritizing smooth throttle inputs and using “Comfort” mode on the highway can yield results closer to, or even slightly above, the EPA estimates.

How it compares

The S5’s fuel economy is similar to its direct rivals. The BMW 440i Coupe, for example, delivers around 25 MPG combined with its inline-six engine. The Mercedes-AMG C43 Coupe offers a bit more performance but typically sees slightly lower numbers in the low 20s for overall MPG. The Infiniti Q60 Red Sport, with its turbocharged V6, also falls in a similar range.

Buyers in this segment recognize that they’re paying for a combination of performance, luxury, and style, and the fuel economy is an accepted part of that. They prioritize the driving experience and badge appeal over ultimate efficiency, but they still expect reasonable fuel consumption from a modern luxury vehicle. For those seeking significantly better fuel efficiency, a hybrid or electric vehicle would be the most logical choice. Those types of vehicles simply don’t offer the same visceral driving experience that the target market is looking for. You can see S5 MPG across all years to explore how this car compares to past model years. Beyond that, check out all Audi fuel economy data on this site for a broader view.

Tips to maximize efficiency

Use “Comfort” or “Efficiency” driving modes whenever possible. The S5’s drive select system allows you to tailor the car’s responsiveness. In these modes, the engine and transmission settings are optimized for fuel conservation, softening throttle response and encouraging earlier upshifts.

Pay attention to tire pressure. Underinflated tires increase rolling resistance, reducing fuel economy. Check your tires regularly and maintain the recommended pressure listed on the doorjamb sticker.

Avoid unnecessary idling. Modern engines are designed to be efficient even at startup. If you anticipate idling for more than a minute, it’s generally more fuel-efficient to turn off the engine.

Practice smooth driving habits. Aggressive acceleration and hard braking consume significantly more fuel. Anticipate traffic flow and maintain a steady pace to minimize wasted energy. The S5’s ample torque means that it can easily maintain speed with minimal throttle input, making this even easier than it might be in another car.

Reduce weight. Carrying unnecessary items in the trunk adds weight and reduces fuel economy. Remove any items that are not essential for daily driving to lighten the load.