The 2021 Mercedes-Benz S560 4matic Coupe achieves 20 MPG combined. This isn’t a number that will thrill anyone shopping for maximum efficiency, but the S560 Coupe isn’t bought as sensible transportation. It’s an indulgence, a statement of success, and a rolling sanctuary for those who prioritize handcrafted luxury and effortless power over pinching pennies at the pump. The relatively low MPG is simply the price of admission into this exclusive club.

City and highway performance

The S560 Coupe’s EPA estimates break down to 16 MPG in the city and 26 MPG on the highway. The city figure reflects the engine’s need to work harder at lower speeds and with frequent stops and starts. The stop/start feature helps in city driving, but can be defeated if preferred.

Expect the 26 MPG highway figure when cruising steadily, which is precisely what the car is designed to do. Long, comfortable journeys are where this car shines, and where you’re most likely to see figures approaching the EPA estimate. Rapid acceleration, even in Comfort mode, will significantly reduce real-world highway mileage.

Annual fuel cost

The EPA estimates the annual fuel cost for the 2021 Mercedes-Benz S560 4matic Coupe at $2,900. This calculation is based on driving 15,000 miles per year and using national average fuel prices. Keep in mind that this number fluctuates depending on driving habits and location, because fuel prices vary considerably from state to state. Premium fuel is also required, which influences the price considerably. The $2,900 figure offers a benchmark, but consider it a floor for most owners of this V8 grand tourer.

Real-world expectations

Expect to see lower fuel economy than the EPA estimates, especially if you enjoy exploring the S560’s power. Spirited driving, frequent short trips, and extended idling all contribute to poorer gas mileage. A heavy foot will easily drop your combined MPG into the mid-teens. Those who prioritize smooth, consistent acceleration and anticipate traffic flow can likely achieve numbers closer to the EPA estimates. Highway driving, in particular, offers the best opportunity for efficiency.

How it compares

Compared to its competitors, the S560 Coupe’s fuel economy is competitive. The BMW 850i xDrive Coupe, with its 4.4L V8, achieves a similar 20 MPG combined. The Lexus LC 500, while visually stunning, manages only 19 MPG combined from its naturally aspirated V8, making the S560 only slightly more efficient. The comparison matters because buyers in this segment are likely cross-shopping these vehicles. However, fuel economy rarely tops the list of priorities for buyers of these flagship coupes. Performance, luxury, and brand cachet tend to weigh far more heavily in the decision-making process. For shoppers interested in all Mercedes Benz fuel economy data outside of the S-Class Coupe, many models offer varying degrees of efficiency if that is a higher priority.

Tips to maximize efficiency

Take advantage of the car’s driving modes. Comfort mode optimizes throttle response and transmission mapping for smooth, efficient driving. Sport and Sport+ modes, while tempting, prioritize performance and will significantly reduce fuel economy.

Practice smooth acceleration and braking. The S560’s abundant torque makes it easy to accelerate quickly, but gentle inputs will save fuel. Avoid unnecessary hard braking by anticipating traffic flow and maintaining a safe following distance. The car’s active driving assists can help maintain a safe following distance.

Ensure your tires are properly inflated. Low tire pressure increases rolling resistance, which reduces fuel economy. Check your tire pressure regularly and inflate to the recommended levels specified on the door jamb sticker.

Minimize idling. The S560’s 4.0L V8 consumes a surprisingly large amount of fuel while idling. Turn off the engine if you anticipate being stopped for more than a minute or two, as this helps to save fuel. The car’s ECO start/stop function is designed for this, but can be disabled for individual sessions via a console button.

Keep up with routine maintenance. A well-maintained engine runs more efficiently. Regular oil changes, air filter replacements, and spark plug services all contribute to optimal fuel economy. Consult the owner’s manual for the recommended maintenance schedule.