25 MPG combined isn’t going to win any hypermiling contests, but it’s a respectable figure for the 2021 Mercedes-Benz E350. This isn’t a car purchased by those solely chasing efficiency. Instead, it’s for drivers prioritizing luxury, technology, and a comfortable driving experience. The E350 delivers on those fronts, and its fuel economy is acceptable given its mission as a refined, executive-class sedan.

City and highway performance

The E350’s EPA estimates break down to 22 MPG in the city and 31 MPG on the highway. The city figure reflects the reality of stop-and-go driving. The 2.0L turbocharged engine, while smooth and responsive, requires more fuel when repeatedly accelerating from a standstill. The highway number is more impressive, showcasing the 9-speed automatic transmission’s ability to keep the engine in its optimal efficiency range at cruising speeds. The E350 excels on longer journeys, offering a quiet and composed ride that minimizes fatigue, a key benefit that offsets slightly less-than-stellar city MPG.

Annual fuel cost

The EPA estimates the annual fuel cost for the 2021 Mercedes-Benz E350 at $2,300. This figure is based on driving 15,000 miles per year and using national average fuel prices. Remember that actual costs will vary depending on your driving habits, local fuel prices, and the grade of gasoline you choose. Mercedes-Benz recommends premium fuel for optimal performance in the E350, which will increase your annual fuel expenses compared to using regular unleaded.

Real-world expectations

While the EPA estimates provide a useful benchmark, real-world fuel economy can differ significantly. Aggressive driving, frequent short trips, and carrying heavy loads will all decrease your MPG. Gentle acceleration, consistent highway speeds, and proper tire inflation can help you achieve or even exceed the EPA estimates. Owners who prioritize fuel economy and adopt efficient driving habits should see figures close to the official numbers, while those who regularly exploit the engine’s power may experience lower MPG.

How it compares

The E350’s fuel economy stacks up reasonably well against its competition. The BMW 530i, with its similar 2.0L turbocharged engine, achieves an EPA-estimated 28 MPG combined. The Audi A6 45 TFSI, another contender in this segment, also posts a 25 MPG combined rating. Though the E350’s fuel economy is not class-leading, the differences are often negligible for buyers in this segment. Owners consider factors beyond just MPG, and many buyers are willing to accept a slight compromise in fuel economy for the E350’s elegant styling, advanced technology, and reputation for comfort. For those particularly concerned about efficiency, the E350e plug-in hybrid offers significantly improved fuel economy, but includes a higher initial purchase price. You can examine E350 MPG across all years to review its history and compare powertrains.

Tips to maximize efficiency

Take advantage of the E350’s driving modes. The “Eco” mode optimizes the engine and transmission settings for maximum fuel efficiency, softening throttle response and encouraging earlier upshifts. While it might not provide the most exhilarating driving experience, it’s an effective way to conserve fuel during everyday commutes.

Maintain proper tire inflation. Underinflated tires increase rolling resistance, forcing the engine to work harder and consuming more fuel. Check your tire pressures regularly and inflate them to the recommended levels found on the doorjamb sticker. This simple step can make a noticeable difference in your MPG.

Avoid unnecessary idling. Letting your engine idle for extended periods wastes fuel. If you’re stopped for more than a minute, turn off the engine. The E350’s refined starter will make re-ignition smooth and barely noticeable.

Anticipate traffic flow and maintain a steady speed. Avoid sudden acceleration and braking, which consume excessive fuel. Looking ahead and adjusting your speed gradually minimizes wasted energy and improves your fuel economy. Smooth, consistent driving is the key to maximizing efficiency in any vehicle, particularly the E350.

Consider using cruise control on the highway. Cruise control helps maintain a constant speed, preventing minor fluctuations in throttle that waste fuel. This is especially effective on long, level stretches of road where you can maintain a consistent pace. For all all Mercedes Benz fuel economy data, FuelEconomyHub.com has you covered.