The 2021 Mercedes-Benz AMG E63 S 4matic Plus wagon achieves 18 MPG combined. To be clear, most people spending over $100,000 on a hand-built, twin-turbocharged, 603-horsepower super wagon aren’t expecting Prius-like efficiency. This machine is built for performance, easily handling winding backroads and autobahn sprints. The fuel economy is simply a price of admission, something considered after deciding to buy this specialized car.

City and highway performance

The EPA estimates 16 MPG in the city and 23 MPG on the highway. Predictably, the city numbers reflect stop-and-go traffic. While exceptionally responsive, the AMG-tuned 9-speed automatic transmission still requires fuel to move over two tons of metal and leather from intersection to intersection. While seemingly low for a modern car, the highway figure isn’t terrible considering the E63 S’s aerodynamic profile (or lack thereof) and its power output. Expect to see closer to 23 MPG on long highway cruises, but only with restraint to avoid using the engine’s reserves, which few owners can do. Remember there is AMG MPG across all years to consider.

Annual fuel cost

The EPA estimates an annual fuel cost of $3,200 for the 2021 Mercedes-Benz AMG E63 S 4matic Plus wagon, a reminder of the price for ownership. This is based on driving 15,000 miles per year, with 55% of those miles in the city and 45% on the highway, using national average fuel prices. Premium fuel is mandatory, and gas price changes can significantly impact that figure. It is just another thing to consider for someone with a large budget for car ownership.

Real-world expectations

Real-world fuel economy will vary based on driving style. Someone who frequently uses the car’s acceleration and exhaust will likely see figures below EPA estimates. A driver who is more restrained, using the car’s comfort settings and minimizing acceleration, might achieve numbers closer to or slightly above the EPA’s combined rating. However, it’s always tempting to use the car’s power, making it hard to consistently achieve optimal fuel economy.

How it compares

The AMG E63 S is in a segment of high-performance wagons where fuel economy isn’t the main concern. Still, it’s worth seeing how it compares agains other vehicles. The Porsche Panamera Turbo Sport Turismo, with its 4.0-liter twin-turbo V8, achieves about 17 MPG combined. The Audi RS6 Avant, also hovers around 18 MPG combined. These figures show the trade-off between performance and efficiency in this category. Buyers are more focused on horsepower, handling, and exclusivity than marginal MPG differences. You can also consult all Mercedes Benz fuel economy data to compare against other vehicles.

Tips to maximize efficiency

Smooth acceleration is important. Avoid sudden speed increases and try to maintain a consistent throttle position, especially on the highway. The twin-turbo V8 responds to even slight throttle inputs, so controlling your foot can make a difference.

Use the car’s drive modes. The “Comfort” mode optimizes the engine and transmission for efficiency, although it is slightly less engaging than “Sport” or “Sport+”. It softens throttle response and encourages earlier upshifts, minimizing fuel consumption.

Pay attention to tire pressure. Ensure your tires are properly inflated to the recommended pressure. Under-inflated tires increase rolling resistance, which hurts fuel economy. This is especially important on a performance car where maintaining handling and braking is critical.

Minimize idling. If you anticipate being stationary for more than a few minutes, turn off the engine. Idling consumes fuel without moving. This is a simple way to conserve fuel, especially in city driving.