25 MPG combined. For a buyer considering the 2021 Mercedes-Benz AMG E53 4matic Plus, that number will either be a deal-breaker or utterly irrelevant. This isn’t a car purchased for maximizing fuel efficiency. It’s a luxury performance sedan (or coupe/cabriolet) offering a strong blend of power, technology, and unmistakable Mercedes-Benz brand appeal. The target customer prioritizes driving enjoyment and a luxurious experience over squeezing every last mile from a gallon of premium fuel. They want the growl of the AMG-enhanced inline-six, the responsiveness of the 4matic Plus all-wheel drive, and the comfort of a meticulously crafted interior. Fuel economy takes a backseat. It’s a tolerated compromise, not a primary consideration.

City and highway performance

The EPA estimates for the E53 break down to 22 MPG in the city and 29 MPG on the highway. The city figure reflects the reality of stop-and-go traffic where the engine’s start/stop system activates, offering some marginal improvement. However, the spirited driving style that the AMG encourages will quickly diminish any gains from that technology.

On the highway, the 29 MPG figure is achievable if you resist the urge to frequently dip into the engine’s ample reserves of power for effortless passing maneuvers. The 9-speed automatic transmission plays an important role here, keeping the engine at optimal RPMs for efficiency at cruising speeds. Just remember that any extended period of aggressive driving will significantly impact that highway MPG.

Annual fuel cost

The EPA estimates the annual fuel cost for the 2021 Mercedes-Benz AMG E53 4matic Plus at $2,300. This figure is based on driving 15,000 miles per year, with a 55/45 split between city and highway driving, and using the national average price for premium unleaded gasoline. It is a useful benchmark for comparing fuel costs among different vehicles, but your actual fuel expenses will vary depending on your driving habits, local fuel prices, and the specific mix of city and highway driving you do.

For example, if you primarily drive in the city and enjoy exploring the engine’s performance, you could easily exceed this $2,300 estimate. If you are interested in all Mercedes Benz fuel economy data, this is a great place to start.

Real-world expectations

Don’t expect to consistently achieve the EPA’s numbers in real-world driving. The AMG E53 is engineered to be driven with gusto, and that inevitably leads to less gas. Expect to see figures closer to the low 20s in mixed driving conditions. Engage the Comfort driving mode and adopt a gentler driving style, and you might approach the EPA estimates, but doing so somewhat defeats the purpose of owning an AMG. To understand the trend of AMG MPG across all years, consider reviewing detailed model histories.

How it compares

Compared to its rivals, the AMG E53’s fuel economy is competitive, but not class-leading. The BMW M550i xDrive, with its more powerful V8, achieves around 20 MPG combined. The Audi S6, with its turbocharged V6, hovers around 22 MPG combined. The Porsche Panamera 4S, a liftback sedan with a turbocharged V6, offers slightly better fuel economy at around 24 MPG combined. The slight efficiency advantage from the Panamera 4S is often offset by its higher price tag and different driving dynamics. For the AMG E53 buyer, the slight fuel economy differences with similar performing sedans are often not a determining factor when other components, like the interior, are taken into consideration.

Tips to maximize efficiency

Use the ECO drive mode carefully. While it may slightly dampen throttle response, it optimizes shift points and engine parameters for less gas. This mode is most effective during relaxed highway cruising or in congested city traffic, but not necessarily the E53’s element.

Pay close attention to tire pressure. Underinflated tires increase rolling resistance, which negatively impacts fuel economy. Regularly check your tire pressure and inflate them to the recommended levels found on the doorjamb sticker.

Avoid unnecessary idling. Modern engines are designed to be efficient, and idling for extended periods wastes fuel. If you anticipate being stationary for more than a minute, turn off the engine.

Minimize aggressive acceleration and hard braking. The instant torque of the AMG E53 is tempting, but repeatedly exploiting it will rapidly deplete your fuel tank. Smooth, gradual acceleration and controlled braking are key to maximizing fuel economy.

Reduce weight in the vehicle. Hauling around unnecessary cargo increases fuel consumption. Remove any items from the trunk and interior that you don’t need on a regular basis.