25 MPG combined is a reasonable figure for the 2020 Mercedes-Benz E350 4matic. Remember that this car is a classically proportioned, luxurious sedan engineered for comfort and refinement, with all-wheel drive adding weight and complexity. Buyers in this segment prioritize effortless driving, a meticulously crafted interior, and the Mercedes-Benz brand. Fuel economy plays a role, but it’s rarely the main reason for purchase. They’re willing to trade a few MPG for the peace of mind and on-road security that 4matic all-wheel drive provides, especially in northern climates where this car is popular.

City and highway performance

The EPA estimates 22 MPG in the city and 30 MPG on the highway for the E350 4matic equipped with the 2.0L turbocharged four-cylinder engine. The city figure reflects stop-and-go driving, where the engine works harder, and the all-wheel-drive system incurs a slight loss. On the open road, at a steady speed, the E350’s nine-speed automatic transmission allows the engine to operate at a fuel-sipping RPM range. The aerodynamic profile of the E-Class also helps its highway efficiency.

Annual fuel cost

According to the EPA, the estimated annual fuel cost for the 2020 Mercedes-Benz E350 4matic is $2,300. This is calculated based on driving 15,000 miles per year, using national average fuel prices. Your actual fuel costs will vary depending on your driving habits, the type of roads you drive on, and fuel prices in your area. Compare this figure against all Mercedes Benz fuel economy data if you are curious about the cost of ownership for other models.

Real-world expectations

While the EPA estimates provide a helpful benchmark, real-world fuel economy can differ. E350 4matic owners often report figures close to the EPA estimates. However, driving style and conditions are important. A driver constantly accelerating hard will likely see lower numbers, especially in the city. A driver who anticipates traffic and employs gentle acceleration and braking techniques could potentially exceed the EPA’s highway estimate. The type of driving that is done will dictate what kind of E350 MPG across all years an owner gets with their specific driving style.

How it compares

The E350’s fuel economy is competitive but not class-leading. The BMW 530i xDrive achieves a similar 25 MPG combined, while the Audi A6 45 TFSI quattro also hovers around 24 MPG combined. The Lexus ES 350, without all-wheel drive, boasts a slightly better 26 MPG combined. These minor differences highlight that fuel economy is similar among these mid-size luxury sedans. Buyers in this segment will weigh fuel economy against other factors, such as brand preference, features, and driving experience.

Tips to maximize efficiency

Use the E350’s drive mode selector. Selecting “Eco” mode will remap the throttle response and shift points to prioritize fuel efficiency. It also enables the ECO start/stop function more readily, shutting off the engine at traffic lights and in stop-and-go traffic, saving fuel that would otherwise be wasted idling.

Maintain proper tire inflation. Underinflated tires increase rolling resistance, forcing the engine to work harder and consume more fuel. Check your tire pressures regularly and inflate them to the recommended levels listed on the sticker inside the driver’s side doorjamb. Just a few PSI can improve efficiency.

Minimize excessive idling. Modern engines are efficient even at startup, making prolonged idling unnecessary. If you anticipate being stopped for more than a minute, such as waiting for someone, it’s more fuel-efficient to turn off the engine and restart it when you’re ready to go.

Anticipate traffic and avoid aggressive driving. Smooth, consistent driving habits are key. Avoid sudden acceleration and hard braking, as these actions waste fuel. Maintain a steady speed and anticipate traffic flow to minimize unnecessary stops and starts.