21 MPG combined won’t win any fuel efficiency awards, but that’s not really the point of the 2019 Mercedes-Benz S560 4matic. This is a flagship sedan, a rolling statement of success and technological prowess, powered by a twin-turbocharged V8 engine. Buyers in this segment prioritize effortless power, opulent comfort, and cutting-edge features over squeezing every last mile from a gallon of premium fuel. For these individuals, the S560 represents the pinnacle of luxury motoring, and the fuel bill is simply a cost to drive it.

City and highway performance

The EPA estimates for the 2019 S560 4matic are 17 MPG in the city and 27 MPG on the highway. These figures reflect the dual nature of the car. In urban environments, the S560’s weight and stop-and-go traffic affects fuel economy. However, on the open road, the 9-speed automatic transmission and the engine’s ability to cruise effortlessly allow for respectable efficiency, especially considering the available power.

Annual fuel cost

According to the EPA, the estimated annual fuel cost for the 2019 Mercedes-Benz S560 4matic is $2,750. This figure is based on driving 15,000 miles per year and using the national average fuel prices at the time of calculation. Remember that actual fuel costs can vary significantly based on individual driving habits, local fuel prices, and the type of fuel used. Given the S560’s requirement for premium fuel, you might spend considerably more depending on fuel prices. This is a worthwhile figure to use if you are considering S560 MPG across all years.

Real-world expectations

While the EPA estimates provide a useful benchmark, real-world fuel economy for the S560 can change depending on driving style and conditions. Those with a heavier foot or who frequently experience traffic congestion in urban areas may see figures closer to the low end of the EPA range, or even slightly below. Conversely, drivers who prioritize smooth acceleration and spend more time on the highway could potentially achieve figures closer to, or even slightly above, the EPA’s highway estimate. We can say that in gentle mixed driving, however, the EPA estimate is mostly accurate.

How it compares

In the world of large luxury sedans, the S560’s fuel economy is broadly comparable to its competitors, but differences do exist. The BMW 750i xDrive, with its 4.4L V8, achieves an EPA-estimated 17 MPG city and 25 MPG highway, slotting it somewhat lower than the S560 in both metrics. The Audi A8’s 3.0L turbocharged V6 manages a better 19 MPG city and 28 MPG highway. The Lexus LS 500 with its 3.5L twin-turbo V6 posts ratings of 19 MPG city and 30 MPG highway. These comparisons matter because even in this segment, some buyers appreciate any advantage in fuel savings. These are small improvements, though, next to considering all Mercedes Benz fuel economy data.

Tips to maximize efficiency

While fuel economy may not be the primary concern for S560 owners, there are ways to optimize efficiency without sacrificing the driving experience. Avoid aggressive acceleration and hard braking, as these maneuvers significantly impact fuel consumption and are generally unbecoming of a vehicle engineered for smooth, refined progress.

Use the car’s driving mode selector to choose the “Comfort” or “Eco” mode when possible. These modes typically optimize engine and transmission settings for fuel efficiency, which will have a real impact in heavy traffic situations. Experimenting with the various driving modes and using them appropriately can subtly but measurably improve fuel economy.

Ensure that the tires are properly inflated to the recommended pressure. Underinflated tires increase rolling resistance, which lowers fuel economy. Checking tire pressure regularly and maintaining the correct inflation levels will not only improve efficiency but also enhance safety and tire life.

Reduce unnecessary weight in the vehicle. Carrying excessive cargo adds to the overall weight, which can negatively impact fuel economy. Removing items you don’t need on a daily basis can make a small but cumulative difference over time.