The 2016 Mercedes-Benz E400 4matic earns an EPA combined rating of 22 MPG, a figure that’s unlikely to impress efficiency enthusiasts, but probably won’t deter the typical buyer. This buyer values power, comfort, and all-weather security and is willing to accept slightly below-average fuel efficiency for the smooth performance and composed ride that define the E400. The 3.0L V6, aided by its 4MATIC all-wheel-drive system, inspires confidence in any driving condition.

City and highway performance

The E400 4matic’s fuel economy breaks down to 20 MPG in the city and 27 MPG on the highway. Naturally, urban driving, with its constant stop-and-go, impacts mileage the most, but the smooth-shifting 7-speed automatic transmission helps to lessen some efficiency loss. The E400 truly shines on the open road. The engine settles into a relaxed cruise, and the aerodynamic design contributes to stable and relatively efficient long-distance travel. The cabin remains quiet even at higher speeds, making those highway miles effortless. Remember that aggressive driving will quickly diminish these numbers.

Annual fuel cost

The EPA estimates an annual fuel cost of $2,650 for the 2016 Mercedes-Benz E400 4matic. This is based on driving 15,000 miles per year and using national average fuel prices. This is just an estimate, and your actual fuel costs may vary depending on how you drive, where you drive, and the price of gasoline in your area. Drivers who primarily drive in the city, or those with a heavier foot, can expect to spend more than the estimated $2,650. Consistent highway driving can result in a lower annual fuel bill.

Before making a purchasing decision, it’s also helpful to look at E400 MPG across all years to get a better sense of the E400’s overall fuel economy.

Real-world expectations

While the EPA estimates provide a useful baseline, real-world fuel economy can differ significantly. Various factors, including driving style, traffic conditions, weather, and even tire pressure, can influence fuel consumption. Some drivers report achieving numbers slightly above the EPA estimates on long highway trips. It can be challenging for others to match the city MPG in congested urban areas. Drivers who frequently use the E400’s Sport mode, which holds gears longer and sharpens throttle response, will also see a decrease in fuel economy. Most owners understand this tradeoff.

How it compares

Compared to its competitors, the 2016 Mercedes-Benz E400 4matic sits in the middle of the pack. The BMW 535i xDrive from the same year, for example, is rated at 20 MPG city and 29 MPG highway, offering a slightly better highway figure. The Audi A6 3.0T Quattro achieves similar numbers, with an EPA rating of 20 MPG city and 30 MPG highway. The Cadillac CTS 3.6L AWD, while offering a sportier driving experience, comes in lower, with a combined rating of 21 MPG. The Lexus GS 350 AWD, known for its reliability, also matches the E400’s 22 MPG combined. These comparisons matter because the E400 buyer is often cross-shopping these vehicles and weighing factors beyond just fuel economy.

Tips to maximize efficiency

Take advantage of the E400’s “Eco” driving mode, if equipped. Selecting this mode adjusts the throttle response and transmission shift points to prioritize fuel efficiency over performance. You’ll notice a more relaxed driving experience, but the fuel savings can be significant, especially during city driving. The Eco setting is best suited for commuting and steady-state cruising.

Keep your tires properly inflated. Underinflated tires increase rolling resistance, forcing the engine to work harder and consume more fuel. Check your tire pressure regularly and inflate them to the manufacturer-recommended specifications, which can be found on the sticker inside the driver’s side doorjamb. A small investment in a tire pressure gauge can pay off in fuel savings over time.

Avoid aggressive driving habits. Rapid acceleration, hard braking, and high-speed cruising all contribute to lower fuel economy. Driving smoothly and predictably, anticipating traffic conditions, and maintaining a consistent speed can significantly improve your MPG. Consider each drive a challenge to minimize unnecessary acceleration and braking.

Reduce unnecessary weight. The heavier the vehicle, the more fuel it consumes. Remove any unnecessary items from the trunk and passenger compartment to lighten the load. Even small amounts of extra weight can add up and impact fuel efficiency, especially during city driving. Regularly decluttering your car is a simple way to boost MPG.

Ensure your E400 receives regular maintenance. A well-maintained engine runs more efficiently. Follow the manufacturer’s recommended maintenance schedule, including oil changes, air filter replacements, and spark plug service. A properly tuned engine will deliver optimal performance and fuel economy. Consider researching all Mercedes Benz fuel economy data for additional insights.