The 2016 Mercedes-Benz E350 4matic’s 23 MPG combined isn’t going to win any hypermiling contests, nor should it. This is a mid-size luxury sedan designed for comfort, safety, and a certain level of prestige, not outright fuel efficiency. The all-wheel-drive system adds weight and complexity, and the smooth, responsive 3.5L V6 prioritizes confident acceleration over squeezing every last drop of fuel. These choices reflect the priorities of the typical E350 buyer: someone who values a comfortable, capable, and prestigious driving experience, even if it means sacrificing a few MPG.

City and highway performance

The EPA estimates the E350 4matic at 20 MPG in the city and 27 MPG on the highway. The city figure reflects the engine’s need to work harder in stop-and-go traffic, where the all-wheel-drive system provides minimal advantage. The highway number is more respectable, showing that the 7-speed automatic transmission can keep the engine at relatively low RPMs during steady-state cruising. However, aggressive passing maneuvers or sustained high speeds on the open road will quickly diminish that 27 MPG figure. The 3.5L V6 delivers its power smoothly, but it still requires fuel to do so. These figures are important to consider alongside E350 MPG across all years.

Annual fuel cost

The EPA calculates the annual fuel cost for the 2016 Mercedes-Benz E350 4matic at $2,500. This figure is based on driving 15,000 miles per year, with 55% of those miles driven in the city and 45% on the highway, using national average fuel prices. It’s critical to understand that this is an estimate.

Your actual fuel costs will vary depending on your driving habits, local fuel prices, and the specific conditions in which you drive. For example, if you do mostly highway driving, and/or live in an area with lower gas prices, your annual fuel expenses might be less. Conversely, if you drive mostly in congested city traffic, or have a heavy foot, you’re likely to exceed that $2,500 figure.

Real-world expectations

While the EPA estimates provide a useful baseline, real-world fuel economy often differs. Many owners find that achieving the stated 27 MPG highway figure is realistic on long trips, particularly when using cruise control and avoiding excessive acceleration. However, the 20 MPG city figure can be harder to achieve during rush hour or in hilly terrain. Overall, a combined MPG in the low 20s is a reasonable expectation for most drivers.

Remember that driving style plays a significant role. The Mercedes-Benz E350 is a refined vehicle, but aggressive driving will certainly impact fuel consumption.

How it compares

Compared to other mid-size luxury sedans with all-wheel drive from the same model year, the E350 4matic’s fuel economy is fairly typical. For example, the 2016 BMW 535i xDrive, with its turbocharged 3.0L inline-6, is rated at 20 MPG city and 30 MPG highway. The Audi A6 3.0T quattro, with its supercharged 3.0L V6, manages 20 MPG city and 30 MPG highway. The Lexus GS 350 AWD offers a similar V6 engine to the E350, but achieves slightly better numbers at 19 MPG city and 26 MPG highway. These slight differences in MPG aren’t usually the deciding factor for buyers in this segment. Power, features, and brand prestige often weigh more heavily. Consider exploring all Mercedes Benz fuel economy data to place your findings in a broader context.

Tips to maximize efficiency

Maintain your tires at the recommended pressure. Underinflated tires increase rolling resistance, forcing the engine to work harder and consume more fuel. Check your tire pressure regularly, especially during seasonal temperature changes.

Avoid unnecessary idling. If you’re stopped for more than a minute, turn off the engine. Modern engines are designed to restart quickly and efficiently, and shutting off the engine will save fuel and reduce emissions. This is especially helpful in the city and in stop-and-go traffic.

Use cruise control on the highway whenever possible. Maintaining a consistent speed minimizes unnecessary acceleration and deceleration, which can significantly improve fuel economy. However, be mindful of traffic conditions and avoid using cruise control in heavy or variable traffic.

Drive smoothly and avoid aggressive acceleration. The E350’s engine is responsive, but each burst of acceleration consumes extra fuel. Gentle acceleration and anticipation of traffic conditions will help you maintain a more consistent speed and improve your MPG.

Keep your car properly maintained. Regular oil changes, air filter replacements, and tune-ups will ensure that your engine is running efficiently. A well-maintained engine consumes less fuel and produces fewer emissions.