22 MPG combined is what anyone considering a 2016 Lexus IS 350 needs to expect. It’s acceptable for a naturally aspirated 3.5L V6 powering a rear-wheel-drive sport sedan, but it’s also not class-leading. The IS 350 isn’t about getting every last mile from a gallon of premium; it’s about a refined, engaging driving experience with traditional Lexus luxury. Buyers accept this fuel economy because they prioritize those qualities, along with the brand’s reputation for reliability, over outright efficiency.

City and highway performance

The EPA estimates for the 2016 IS 350 are 19 MPG in the city and 28 MPG on the highway. The city figure reflects the engine’s fast response during stop-and-go driving, where the 3.5L V6 delivers smooth acceleration. 28 MPG on the highway isn’t setting any records, but it’s adequate for comfortable long-distance cruising, especially when using the car’s adaptive cruise control system to maintain consistent speeds and minimize unnecessary throttle inputs. The IS 350 is often marketed as a sport sedan, but its 8-speed automatic transmission is tuned more for smoothness than aggressive gear changes, improving highway fuel economy.

Annual fuel cost

The EPA estimates an annual fuel cost of $2,650 for the 2016 Lexus IS 350. This is based on driving 15,000 miles per year and using the national average fuel price for premium gasoline, which the IS 350 requires. Your actual costs may vary depending on your driving habits, local fuel prices, and the percentage of city versus highway driving you typically do. Buyers should also remember that this figure changes with gasoline prices, so projecting fuel costs over the long term is important while considering all Lexus fuel economy data.

Real-world expectations

The EPA provides a standardized testing method, but real-world fuel economy can vary based on driving style and conditions. If you primarily drive on the highway and drive conservatively, expect to see numbers close to the EPA estimates—maybe even slightly better. Aggressive acceleration, frequent hard braking, and prolonged idling will negatively impact fuel economy, potentially bringing the average down to the lower end of the EPA range, or even slightly below the 22 MPG combined figure. Understanding IS MPG across all years can provide a better long-term expectation based on model years and driving styles.

How it compares

The 2016 IS 350’s fuel economy isn’t class-leading. For instance, a 2016 BMW 340i, with its turbocharged 3.0L inline-six, achieves a combined MPG of 25. This is a noticeable difference because of BMW’s focus on efficient performance. An Audi S4 from the same year, with its supercharged 3.0L V6, achieves 24 MPG combined. Even the Infiniti Q50, another V6-powered competitor, manages a slightly better 23 MPG combined in some trims. These small differences might sway buyers who prioritize fuel economy, but the IS 350 counters with its reputation for reliability and Lexus’ renowned ownership experience.

Tips to maximize efficiency

First, use the IS 350’s drive mode selector. Selecting “Eco” mode alters the throttle response and transmission mapping to prioritize fuel efficiency over performance. It diminishes some of the car’s sporty feel, but it noticeably improves fuel economy, especially during city driving.

Second, check tire pressure. Maintaining the correct tire pressure, as indicated on the doorjamb sticker, reduces rolling resistance and improves fuel economy. Check your tire pressure regularly, especially during temperature changes, as pressure can change.

Removing unnecessary weight in the vehicle can also improve fuel economy. Items removed from the trunk or backseat that are not essential can lighten the load on the engine and reduce fuel consumption. This is especially important for city driving, where frequent stops and starts require more energy to accelerate.

Finally, avoid aggressive driving habits, because rapid acceleration and hard braking consume significantly more fuel. Anticipate traffic conditions and maintain a smooth, consistent speed to minimize fuel consumption. Using the car’s cruise control system on the highway can also help maintain a constant speed and improve fuel economy.