The 2018 Mercedes-Benz E300 4matic, equipped with its 2.0L turbocharged four-cylinder engine, gets an EPA-estimated 24 MPG combined. While not the most fuel-efficient vehicle in its class, it offers an acceptable compromise for buyers seeking a mix of luxury, technology, and all-weather capability. The E300 4matic is designed for professionals, executives, and established individuals who value refinement and brand prestige along with fuel efficiency.

City and highway performance

The EPA estimates 21 MPG in the city and 29 MPG on the highway. This difference reflects the E300’s performance characteristics. In urban stop-and-go traffic, the 2.0L engine works harder, and the 4matic all-wheel drive system adds weight and friction. However, highway driving allows the engine to operate in its most efficient range, aided by the smooth-shifting 9-speed automatic transmission. The long top gear helps reduce fuel consumption. Drivers who spend more time on the open road will likely see closer to that 29 MPG figure.

Annual fuel cost

The EPA estimates the annual fuel cost for the 2018 Mercedes-Benz E300 4matic at $2,400. This is based on driving 15,000 miles per year, using a national average fuel price. This is only an estimate, actual fuel costs will vary depending on driving habits, fuel type (premium is recommended for best performance), and local fuel prices. Aggressive driving and frequent short trips will increase this number, while careful driving on longer trips can lower it.

Real-world expectations

EPA figures provide a baseline, but real-world MPG may differ. Owner reports suggest that achieving the EPA’s 29 MPG highway figure is possible, especially on flat roads with conservative driving. The 21 MPG city estimate can be harder to achieve, particularly in areas with heavy traffic. Expect the low-to-mid 20s for mixed driving. Tire pressure, vehicle maintenance, and even weather can impact overall fuel efficiency. You can see E300 MPG across all years here.

How it compares

The E300 4matic’s fuel economy is midrange compared to its competitors. The BMW 530i xDrive, a direct rival, also achieves a combined 24 MPG. The Audi A6 2.0T Quattro offers similar performance, with a combined 25 MPG. The Volvo S90 T5 FWD, using front-wheel drive instead of all-wheel drive, achieves slightly better numbers at 26 MPG combined. The E300 provides luxury, safety, and performance. Mercedes build quality and brand prestige are other factors.

You can also review all Mercedes Benz fuel economy data to see how it all stacks up.

Tips to maximize efficiency

Use the E300’s driving modes. Select “Eco” mode when performance is less important, such as on the highway or in light city traffic. This mode optimizes the engine and transmission for fuel efficiency. “Sport” mode prioritizes power and responsiveness, which will reduce MPG.

Check tire pressure. Underinflated tires increase rolling resistance, lowering fuel economy. Check your tire pressure regularly and inflate them to the recommended level (listed on the driver’s side doorjamb). A simple tire pressure gauge can make a difference.

Minimize idling. Avoid unnecessary idling, especially in cold weather. Modern engines warm up quickly while driving and prolonged idling wastes fuel. If you’re stopping for over a minute, turn off the engine.

Drive smoothly. Aggressive acceleration and hard braking use more fuel. Practice smooth acceleration and anticipate traffic to avoid unnecessary braking. Maintaining a steady speed on the highway improves fuel efficiency.

Keep up with maintenance. Regular maintenance, including oil and filter changes and spark plug replacements, ensures the engine runs efficiently. A well-maintained engine burns fuel more cleanly and efficiently.