21 MPG combined. That figure likely isn’t the primary selling point of the 2018 Mercedes-Benz AMG E43 4matic, nor should it be. This car exists where luxury, performance, and all-weather practicality meet, meaning fuel efficiency plays a supporting role. Buyers in this segment prioritize the exhilarating power of the turbocharged 3.0-liter V6, the sure-footed grip of all-wheel drive, and the opulent comfort of a meticulously crafted interior. They accept the E43’s fuel consumption as a necessary trade-off for the experience it delivers.

City and highway performance

The EPA estimates the 2018 AMG E43 at 19 MPG in the city and 25 MPG on the highway. While these figures aren’t exactly Prius-level, they are respectable considering the car’s purpose. The city number reflects stop-and-go driving, where the E43’s twin-turbo V6 is constantly accelerating and decelerating. The highway figure shows the potential for better efficiency during sustained cruising speeds. The 9-speed automatic transmission helps in this regard, allowing the engine to operate at lower RPMs when possible.

Annual fuel cost

According to the EPA, the annual fuel cost for the 2018 Mercedes-Benz AMG E43 4matic is approximately $2,750. This figure is based on driving 15,000 miles per year and using national average fuel prices, which fluctuate over time. Your actual fuel costs will vary depending on your driving habits, location, and current fuel prices. The $2,750 serves as a useful benchmark for understanding the E43’s running costs.

Real-world expectations

While the EPA numbers provide a baseline, real-world fuel economy can change significantly. Drivers who accelerate quickly or who spend most of their time in aggressive driving modes will likely see lower numbers. Those who prioritize smooth acceleration and use the car’s various efficiency features might achieve figures closer to, or even slightly above, the EPA estimates. The E43’s all-wheel-drive system, while beneficial for grip, also adds weight and contributes to higher fuel consumption. The quality of gasoline used can also impact efficiency; using premium fuel as recommended is a must.

How it compares

The AMG E43 exists in a crowded segment, with several competitors offering similar combinations of performance and luxury. The BMW M550i xDrive, with its 4.4-liter V8, offers significantly more power but also gets worse fuel economy, typically around 18 MPG combined. The Audi S6, equipped with a 4.0-liter V8, is another contender, achieving roughly 21 MPG combined. Some less sporty competitors, like the Volvo S90 T6 AWD, achieve similar economy (25 MPG combined) while prioritizing comfort and luxury over outright performance. For buyers considering AMG MPG across all years, this comparison is critical. For those wishing to view all Mercedes Benz fuel economy data this can help in their decision.

Tips to maximize efficiency

Use “Comfort” mode for daily driving. The AMG E43 features multiple driving modes that alter throttle response, transmission mapping, and suspension settings. Engaging “Comfort” mode softens the throttle and encourages earlier upshifts, which promotes fuel savings. Avoid “Sport” or “Sport+” modes unless you specifically need the extra performance.

Minimize idling. Letting the engine idle for extended periods consumes fuel unnecessarily. If you’re stopped for more than a minute or two, turn off the engine. The E43’s start/stop system can help with this, though some drivers find it intrusive and prefer to disable it.

Maintain proper tire pressure. Underinflated tires increase rolling resistance, which hurts fuel economy. Check your tires regularly and inflate them to the recommended pressure listed on the doorjamb. This small act can noticeably improve efficiency.

Anticipate traffic flow. Aggressive acceleration and braking consume more fuel. By anticipating traffic conditions and maintaining a smooth, consistent speed, you can minimize fuel waste. Leave plenty of following distance and avoid sudden maneuvers.

Remove unnecessary weight. Carrying extra weight in your car reduces fuel economy. Remove any items you don’t need, such as golf clubs, tools, or other heavy objects. A lighter load makes it easier for the engine to propel the car forward.