23 MPG combined isn’t going to win any hypermiling awards, but for the 2016 Mercedes-Benz E350 with its smooth 3.5L V6, it’s a figure that most owners find perfectly acceptable. This car isn’t about squeezing out every last drop of fuel; it’s about effortless performance, luxurious comfort, and a refined driving experience, and the fuel economy is simply part of the cost.

City and highway performance

The EPA estimates break down to 20 MPG in the city and 28 MPG on the highway. The city figure reflects the E350’s weight and the demands of stop-and-go traffic, where the 3.5L engine needs to work a bit harder to get the car moving.

The highway number is more representative of this car’s strong suit: long-distance cruising. The 7-speed automatic transmission allows the engine to settle into a relaxed state at highway speeds, contributing to the respectable MPG. Drivers who frequently commute in heavy traffic will naturally see figures closer to the 20 MPG mark.

Those who prioritize highway driving should achieve numbers closer to, or even surpassing, the EPA’s 28 MPG estimate.

Annual fuel cost

The EPA calculates the annual fuel cost for the 2016 Mercedes-Benz E350 at $2,500. This figure is based on driving 15,000 miles per year and using the national average fuel price at the time of calculation. Keep in mind this figure is an estimate and your actual fuel costs will vary depending on your driving habits, local fuel prices, and the type of fuel you use. While $2,500 might seem significant, those in the market for a luxury sedan typically understand that owning such a vehicle comes with associated costs, and fuel is just one piece of that puzzle.

Real-world expectations

Forget the lab results for a moment. The real-world MPG you achieve in a 2016 E350 depends heavily on how you drive. A heavier foot will quickly erode those EPA numbers, while a more considered approach can yield surprising results. Owners report averaging around 22-25 MPG in mixed driving scenarios. The E350’s onboard computer provides a running average MPG, allowing drivers to track their fuel consumption and adjust their driving style accordingly.

Ultimately, the E350’s fuel economy is not stellar, but most drivers in this segment care more about reliability, comfort, and cachet, more information can be found on E350 MPG across all years.

How it compares

Compared to its rivals, the 2016 E350 sits squarely in the middle of the pack. A BMW 535i from the same year, with its turbocharged inline-six, is often cited as achieving slightly better MPG, hovering around 24 MPG combined.

Conversely, an Audi A6 3.0T, with its supercharged V6, tends to be slightly less fuel-efficient, often averaging around 22 MPG combined. The Lexus GS 350, known for its reliability, posts similar numbers to the E350. For buyers considering the E350, the slightly better fuel economy of the BMW 535i or the similar MPG ratings of the Lexus GS 350 might be a factor, but ultimately, the decision often comes down to brand preference, driving dynamics, and interior design.

For those looking for more options, all all Mercedes Benz fuel economy data can be easily compared.

Tips to maximize efficiency

The E350’s 7-speed automatic is programmed to shift early and often to maximize fuel economy, so using “Eco” mode will further enhance that characteristic. In this mode, the car will prioritize efficiency over outright acceleration, resulting in smoother starts and a more relaxed driving experience. Get used to this mode around town for the best MPG.

Ensure your tires are properly inflated. Underinflated tires create more rolling resistance, forcing the engine to work harder and reducing fuel economy. Check your tire pressure regularly and inflate them to the recommended levels, which can be found on the sticker inside the driver’s side doorjamb.

Anticipate traffic flow and avoid abrupt acceleration and braking. Maintaining a consistent speed and anticipating traffic lights can significantly improve your fuel economy. This driving technique is known as “smooth driving” and is particularly effective in city driving scenarios.

Reduce unnecessary weight. Carrying extra cargo in the trunk adds weight to the vehicle, which in turn reduces fuel economy. Remove any unnecessary items from the trunk and backseat to lighten the load and improve MPG. A lighter car is always a more efficient car.