20 MPG combined won’t win any efficiency awards, but that’s also not the primary concern for someone considering the 2016 Mercedes-Benz CLS550 4matic. This isn’t a car bought for its frugality; it’s a statement. It’s a statement about style, about presence, about a willingness to prioritize a smooth, powerful driving experience over maximizing miles per gallon. The CLS550 buyer wants a refined luxury coupe with a surprising amount of practicality baked in, four doors, a usable trunk, and all-weather security thanks to the 4matic all-wheel-drive system.

City and highway performance

The official EPA estimates peg the CLS550 4matic at 17 MPG in the city and 25 MPG on the highway. That city figure reflects the demands placed on the 4.7L twin-turbo V8 engine in stop-and-go conditions, where its considerable power isn’t put to good use. The highway number, however, is more respectable. The nine-speed automatic transmission allows the engine to cruise at relatively low RPMs, contributing to quieter and more fuel-efficient long-distance travel. Remember that these numbers are based on standardized testing procedures. Individual driving habits and conditions have a significant impact on real-world results.

Annual fuel cost

The EPA estimates the annual fuel cost for the 2016 Mercedes-Benz CLS550 4matic at $2,900. This figure is based on driving 15,000 miles per year, with an assumed fuel price reflecting national averages. Keep in mind that the price of premium gasoline (which the CLS550 requires) fluctuates considerably depending on location and market conditions. Therefore, the actual amount you spend on fuel could be higher or lower than this estimate. This figure is a useful benchmark, but it’s important to consider your personal driving patterns and local fuel prices for a more accurate prediction.

Real-world expectations

While the EPA numbers provide a baseline, expect some variance in everyday driving. Aggressive acceleration, frequent short trips, and heavy city traffic will all negatively affect fuel economy. Conversely, consistent highway driving at moderate speeds will yield closer to the 25 MPG figure, potentially even exceeding it slightly if you adopt efficient driving techniques. Don’t expect hybrid-like numbers, but a realistic driver with a mix of city and highway miles can aim for something close to the combined 20 MPG rating. You can explore CLS550 MPG across all years.

How it compares

Compared to other luxury performance sedans of its era, the CLS550’s fuel economy lands in the middle of the pack. For example, the BMW 550i xDrive with its 4.4L V8 was rated at 17 MPG city and 25 MPG highway, mirroring the CLS550 almost identically. The Audi S6 with its turbocharged V8 achieved similar figures.

However, models with smaller, turbocharged engines like the Mercedes-Benz E400 (20 MPG city / 29 MPG highway) offered better economy, albeit with less raw power. The Porsche Panamera, known for its performance focus, often had models with similar or slightly worse fuel economy depending on the specific engine configuration. This comparison is important to the buyer because while fuel economy isn’t a top priority, they still want to be reasonably competitive within the segment. The CLS550 occupies a sweet spot: delivering impressive performance while not being outrageously inefficient for its class. You can review all Mercedes Benz fuel economy data to see how it stacks up against its stablemates.

Tips to maximize efficiency

Although the CLS550 isn’t primarily about fuel economy, small changes in driving habits can make a difference. Avoid aggressive acceleration and hard braking. The 4.7L V8 has immense power available, but using it judiciously will conserve fuel. Anticipate traffic flow and maintain a steady speed whenever possible.

Ensure the tires are properly inflated. Underinflated tires increase rolling resistance, which reduces fuel economy. Check the tire pressure regularly and maintain the recommended levels, which can be found on the doorjamb sticker or in the owner’s manual.

Minimize idling. If you’re stopped for more than a minute, turn off the engine. Modern engines are designed to restart quickly and efficiently, so there’s no need to let the engine idle unnecessarily. Idling consumes fuel without moving the car.

Use cruise control on the highway. Cruise control helps maintain a consistent speed and avoid unnecessary acceleration and deceleration, both of which contribute to lower fuel economy. This is especially helpful on long road trips.