With 92 MPG combined, the 2025 Mercedes-Benz EQS 450 4matic is one of the most efficient luxury vehicles available. This is quite an achievement for a car focused on comfort, technology, and all-weather security. It’s a flagship Mercedes-Benz sedan that uses electrons instead of gasoline. The EQS 450 4matic appeals to buyers who want luxury and technology while valuing lower fuel costs and the convenience of electric vehicle (EV) ownership.

City and highway performance

The EPA estimates are very close across different driving conditions: 91 MPG in the city and 93 MPG on the highway. These figures highlight the consistent efficiency of the electric powertrain, which isn’t penalized by stop-and-go traffic like an internal combustion engine. The EQS 450 4matic uses regenerative braking to recapture energy when slowing down, a feature that significantly boosts efficiency in urban environments. On the highway, the EQS benefits from its aerodynamic design and efficient electric motor, maintaining impressive efficiency even at higher speeds.

Annual fuel cost

The EPA estimates the annual fuel cost for the 2025 Mercedes-Benz EQS 450 4matic at $850. This is based on driving 15,000 miles per year and using national average electricity prices. For drivers used to refueling a traditional luxury sedan, this is significant savings. This low running cost matters to EQS buyers, who often want a smaller environmental footprint and appreciate the long-term cost benefits of EV ownership. Drivers can reduce their annual fuel costs further by charging their EQS 450 4matic during off-peak hours to get lower electricity rates.

Real-world expectations

The EPA estimates are a good baseline, but real-world range can change based on driving style, weather, and terrain. Fast acceleration, climate control use, and cold temperatures can lower efficiency. The EQS 450 4matic’s energy management system and driver-selectable driving modes help reduce these effects. Most owners should get numbers close to the EPA estimates in normal driving. Drivers of this vehicle know that the posted numbers are a starting point and consciously manage range as EV owners.

How it compares

The EQS 450 4matic has exceptional efficiency compared to gasoline-powered cars. A comparable Mercedes-Benz S-Class might get around 22 MPG combined, resulting in much higher fuel costs. The EQS also shows strong efficiency compared to other luxury EVs. The Tesla Model S Long Range gets about 120 MPGe combined, while the Audi e-tron GT delivers around 82 MPGe combined. See EQS MPG across all years. The BMW i7 xDrive60 achieves 87 MPGe. The EQS provides a good balance, with range and efficiency alongside the luxury features Mercedes-Benz is known for. Shoppers look at these numbers because they want performance and luxury with a smaller carbon footprint.

Tips to maximize efficiency

An effective way to maximize the efficiency of the EQS 450 4matic is to use its regenerative braking system. A higher regenerative braking setting recaptures more energy when decelerating, reducing reliance on the friction brakes and extending range. If you anticipate traffic, lift off the accelerator early to allow the regenerative braking to slow the car down smoothly.

Preconditioning the cabin temperature while the car is plugged in can also improve efficiency. By heating or cooling the cabin before driving, you reduce the energy the battery needs to maintain a comfortable temperature on the road. This can help in extreme weather.

Driving in “Comfort” or “Eco” mode can also maximize efficiency. These modes optimize the powertrain settings for efficiency, reducing throttle response and limiting energy consumption. “Sport” mode provides quicker acceleration at the cost of reduced range.

Proper tire inflation is critical for maximizing fuel efficiency. Underinflated tires increase rolling resistance, requiring more energy to move the car forward. Check your tire pressure regularly and inflate them to the recommended levels to optimize efficiency and extend tire life. Consider that all Mercedes Benz fuel economy data improves with this simple step.