The 2025 Audi S4 3.0L 6-cyl achieves 24 MPG combined. This isn’t about chasing Prius-level efficiency. The S4 buyer wants a strong blend of performance and luxury in a subtly aggressive package. They understand the trade-off between fast acceleration and good fuel consumption, and they’re willing to pay that price. This MPG reflects that compromise, a respectable number for a car that delivers strong acceleration.

City and highway performance

The EPA estimates suggest 20 MPG in the city and 29 MPG on the highway. The city number could be a problem for some. Stop-and-go traffic, combined with the S4’s quick throttle, can negatively impact fuel economy. However, the 29 MPG highway rating is more attainable, especially on longer road trips where the engine cruises more efficiently. Using adaptive cruise control and carefully monitoring your speed can help improve highway MPG, but avoid constantly flooring it.

Annual fuel cost

The EPA estimates an annual fuel cost of $2,400 for the 2025 Audi S4. This calculation is based on driving 15,000 miles per year, using a mix of city and highway driving, and assumes national average fuel prices. This is just an estimate as your actual fuel costs will vary depending on your driving habits, the type of fuel you use (premium is recommended for the S4), and local fuel prices. Drivers who mainly drive in the city or have a lead foot can expect to exceed that $2,400 figure significantly.

Real-world expectations

The EPA numbers provide a useful baseline, but real-world fuel economy can vary. The S4’s supercharged V6 encourages spirited driving, and frequent use of “S” (Sport) mode will affect your MPG. Aggressive acceleration, rapid braking, and high-speed cruising all reduce fuel economy. In contrast, a more conservative driving style, anticipating traffic, and avoiding unnecessary idling can bring you closer to the EPA estimates. Some owners see numbers around 22 MPG combined in mixed driving, but it’s dependent on how you drive.

How it compares

The S4’s fuel economy is competitive within its segment. The BMW M340i, another performance sedan, gets a slightly better 26 MPG combined using its turbocharged inline-six. The Mercedes-AMG C43, with its greater performance, typically gets lower fuel estimates. The Genesis G70 3.3T offers similar performance and luxury at a similar price, but its fuel economy often mirrors the S4’s. For those considering all Audi fuel economy data, the smaller A4 offers better economy, but sacrifices performance. These numbers matter to the S4 buyer because they are cross-shopping these vehicles. They’re willing to sacrifice some fuel economy for the S4’s style, performance, and all-weather capability, thanks to its standard quattro all-wheel drive. If higher mileage is the goal, this buyer is probably looking at a different type of vehicle.

Tips to maximize efficiency

Avoid aggressive acceleration. The S4’s supercharged engine offers instant power, but using it at every chance will drastically reduce fuel economy. Focus on smooth, gradual acceleration and anticipate traffic to minimize the need for hard braking.

Use “Comfort” or “Efficiency” drive modes when you can. The S4 offers drive modes that adjust throttle response, shift points, and steering feel. Selecting “Comfort” or “Efficiency” softens the throttle response and encourages earlier upshifts, which improves fuel efficiency. Even in these modes, the S4 still has a lot of power.

Maintain proper tire inflation. Underinflated tires increase rolling resistance, which reduces fuel economy. Check your tire pressure regularly and inflate to the recommended pressure listed on the driver’s side door jamb. This simple step makes a difference.

Consider a fuel additive designed to improve fuel economy. Some fuel additives can help clean fuel injectors and improve combustion efficiency. Look for reputable brands and follow the instructions. The S4 requires premium fuel, so keeping the fuel system clean is helpful.

Plan your routes. Avoiding congested areas and stop-and-go traffic can improve fuel economy. Use navigation apps to identify potential bottlenecks and choose alternative routes that minimize idling and frequent acceleration and deceleration. Planning can help you match the S4 MPG across all years.