The 2024 Lexus TX 350, with its 2.4L 4-cylinder engine, gets a combined fuel economy of 23 MPG. That figure, while not groundbreaking, is a calculated compromise to offer ample space, a luxurious experience, and the reliability expected from Lexus, all at a competitive price. This isn’t a vehicle for hypermilers; it’s for families and professionals who want a comfortable and confident ride more than segment-leading fuel efficiency.

City and highway performance

The EPA estimates the TX 350 gets 21 MPG in the city and 27 MPG on the highway. The city number reflects the realities of stop-and-go traffic, where the engine’s turbocharger may be frequently engaged to maintain momentum. The highway figure, while better, also shows the TX’s size and aerodynamics. This isn’t a sleek sports car; it’s a substantial three-row SUV built for long-distance cruising. The eight-speed automatic transmission makes the most of the engine’s powerband, but physics still affect overall fuel consumption.

Annual fuel cost

The EPA estimates the annual fuel cost for the 2024 Lexus TX 350 at $2,500. This is based on driving 15,000 miles per year, using national average fuel prices. It’s a standardized benchmark for comparison, but individual fuel costs will vary depending on driving habits, location, and prevailing gas prices. Remember that $2,500 is just an estimate; aggressive driving or consistently using premium fuel (if recommended) will push that number higher. You can find all Lexus fuel economy data on our site.

Real-world expectations

EPA numbers are a baseline, but real-world fuel economy can differ. Drivers who frequently carry passengers or cargo, or who live in hilly areas, may see lower numbers. However, those who primarily drive on flat highways at consistent speeds might exceed the EPA estimate. The TX 350 also has selectable drive modes, including an “Eco” mode, which can help fuel efficiency by adjusting throttle response and transmission mapping. Don’t expect a big difference; it’s more about optimizing efficiency than fundamentally altering the vehicle’s character. To see detailed TX MPG across all years, check out our specific page.

How it compares

In the competitive three-row SUV segment, the Lexus TX 350’s fuel economy is in the middle. The Acura MDX, with its standard 3.5L V6, gets a combined 22 MPG. The Volvo XC90 B5, with its turbocharged and supercharged 2.0L four-cylinder, manages a slightly better 25 MPG combined. The Infiniti QX60, also with a V6 engine, returns around 23 MPG combined, similar to the TX 350. The main difference is in powertrain refinement and driving experience. The XC90 prioritizes efficiency, even with some engine noise at higher RPM. The MDX and QX60 offer more traditional V6 performance, while the TX offers a balance of turbocharged power and Lexus refinement, with fuel economy being an important consideration. The Toyota Grand Highlander with a similar engine achieves slightly higher numbers. The customer considering the TX 350 isn’t only focused on fuel economy; they are also weighing brand reputation, build quality, and the overall ownership experience.

Tips to maximize efficiency

Use the TX 350’s “Eco” drive mode, especially during routine commutes. The mode optimizes throttle response and shift patterns to save fuel. While it won’t change the driving experience completely, it can make a noticeable difference over time, particularly in stop-and-go traffic.

Make sure your tires are properly inflated to the recommended pressure, which you can find on the driver’s side doorjamb. Underinflated tires increase rolling resistance, decreasing fuel economy. Regularly checking and maintaining proper tire pressure is a simple way to improve efficiency and extend tire life.

Avoid aggressive acceleration and braking. The TX 350’s turbocharged engine responds well to smooth, deliberate inputs. Hard acceleration burns fuel unnecessarily, and sudden braking wastes kinetic energy. Predict traffic flow and keep a steady pace whenever possible.

Keep your TX 350 properly maintained according to the recommended service schedule. Regular oil changes, air filter replacements, and other routine maintenance tasks ensure the engine runs efficiently. A well-maintained engine consumes less fuel and produces fewer emissions.

Reduce unnecessary weight. Carrying extra cargo in the TX 350 adds to its overall weight, hurting fuel economy. Remove any items you don’t need, such as sporting equipment or tools, to lighten the load and improve efficiency when not needed.