23 MPG combined isn’t the main reason someone buys a 2023 Mercedes-Benz S500 4matic, and Mercedes-Benz is aware of this. It’s a limousine-class sedan designed for effortless performance and exceptional comfort, not for maximizing fuel economy. S500 buyers prioritize a quiet and technologically advanced ride, accepting higher fuel consumption as the cost for the car’s high level of performance.

City and highway performance

The EPA estimates the S500 4matic gets 20 MPG in the city and 28 MPG on the highway. This difference shows how the turbocharged 3.0L inline-six engine performs in different driving conditions. Stop-and-go traffic is hard on any engine, and the S500’s weight (over 4,600 pounds) makes it worse. However, the engine’s efficiency is clear on the open road, especially with the smooth-shifting 9-speed automatic transmission choosing the best gear for cruising. The 4matic all-wheel-drive system improves traction and stability, but it also lowers fuel economy slightly compared to rear-wheel-drive competitors.

Annual fuel cost

The EPA says the annual fuel cost for the 2023 Mercedes-Benz S500 4matic is $2,500. This is based on driving 15,000 miles per year and using national average fuel prices. Fuel costs change and individual driving habits differ, so this number should be seen as an estimate.

Real-world expectations

EPA figures are a starting point, but S500 4matic drivers will likely see different fuel economy in real-world conditions. Fast acceleration, frequent short trips, and regular use of power-consuming features (like the advanced climate control or massaging seats) will reduce fuel efficiency. On the other hand, careful driving and mainly highway miles can bring results closer to, or even a bit above, the EPA estimates. Checking S500 MPG across all years can provide a more complete view.

How it compares

The S500 4matic’s fuel economy is competitive among flagship luxury sedans with all-wheel drive, but not the best. The BMW 740i xDrive, with its turbocharged inline-six, gets about 25 MPG combined. The Audi A8 55 TFSI quattro, which has a turbocharged V6 and all-wheel drive, gets the same. The Lexus LS 500 AWD reports slightly better combined MPG at 21. These numbers do matter to some people, even at this price, because they show overall efficiency and long-term costs. But buyers often weigh these numbers against other things such as brand preference, how nice the interior is, and the technology included.

Tips to Maximize Efficiency

Use the S500’s drive mode selector. The “Eco” mode changes engine and transmission settings to maximize fuel efficiency, softening how the throttle responds and shifting earlier to keep the engine at its most efficient RPM. Using this mode for daily commutes can improve MPG.

Make sure your tires have the correct amount of air. Underinflated tires increase rolling resistance, which makes the engine work harder, reducing fuel economy. Check your tire pressure regularly and inflate them to the recommended level listed on the driver’s side door or in the owner’s manual.

Avoid idling for long periods. Letting the engine idle, especially when it’s cold, wastes gas. If you’re stopped for more than a minute, turn off the engine. The S500 restarts quickly and smoothly, making it easy to save fuel this way.

Plan routes well. Stay away from congested areas and use routes with consistent speeds and few stops. The navigation system can show traffic patterns and help you choose the most efficient route.

Schedule regular maintenance. A well-maintained engine is more efficient. Follow the recommended maintenance schedule, including oil changes, air filter replacements, and spark plug inspections, to keep your S500 running well. You can find all Mercedes Benz fuel economy data on our website.