24 MPG combined isn’t likely the most important figure for a 2022 Mercedes-Benz S500 4matic. Potential S-Class owners are likely prioritizing opulence, technology, and quiet cruising. Fuel economy is a consideration, but a secondary one to the driving experience, cabin appointments, and the statement an S-Class makes. This MPG figure is in the middle of its class, an acceptable trade-off for its refined powertrain and cutting-edge features.

City and highway performance

The EPA estimates the S500 4matic will achieve 21 MPG in city driving. This respectable figure is aided by the car’s 48-volt mild-hybrid system, which allows the engine to start and stop to save fuel and provides a small electric boost to help acceleration, reducing strain on the gasoline engine at lower speeds. On the open highway, the S500 shines, achieving an estimated 30 MPG. This impressive number is thanks to the efficient 3.0L inline-six engine, the smooth-shifting 9-speed automatic transmission, and the car’s aerodynamic design, all of which allow relaxed and economical long-distance travel.

Annual fuel cost

According to the EPA, the estimated annual fuel cost for the 2022 Mercedes-Benz S500 4matic is $2,400. This figure is based on driving 15,000 miles per year, with 45% of those miles driven in the city and 55% on the highway, using national average fuel prices. While this cost might seem significant, luxury vehicles like the S-Class often require premium fuel, which is typically more expensive than regular gasoline. For buyers considering an S-Class, this $2,400 annual fuel cost is likely a manageable expense relative to the overall cost of ownership and the prestige associated with the vehicle.

Real-world expectations

While the EPA estimates provide a useful benchmark, real-world fuel economy can vary depending on driving habits, traffic conditions, and climate. Aggressive acceleration, frequent hard braking, and prolonged idling will negatively impact fuel efficiency. Conversely, smooth, consistent driving, using cruise control on the highway, and avoiding unnecessary idling can help drivers achieve or even exceed the EPA estimates. Weather conditions can also play a role, with colder temperatures generally reducing fuel economy due to increased engine friction and the use of energy-intensive features like the heater and defroster. Expect numbers slightly below the EPA estimates in demanding conditions, and potentially higher figures in ideal scenarios.

How it compares

The S500’s fuel economy is competitive within the full-size luxury sedan segment, but it’s not class-leading. The BMW 740i, for example, achieves an EPA-estimated 25 MPG combined, slightly better than the S500. The Genesis G90, with its base V6 engine, is rated at 20 MPG combined, lower than the Mercedes. Even the Lexus LS 500, is rated at 25 MPG combined. These differences, while seemingly small on paper, can add up over time. However, buyers often weigh these figures against other factors, such as brand reputation, technology offerings, and overall driving experience. Someone prioritizing the iconic status of a Mercedes-Benz, or its cutting-edge MBUX infotainment system, might accept slightly lower fuel economy than they’d get from a rival.

Tips to maximize efficiency

Take advantage of the S500’s driving modes. The “Eco” mode optimizes engine and transmission settings for maximum fuel efficiency. It reduces throttle response and encourages earlier upshifts, promoting a more relaxed driving style that can lead to less gas usage, especially during city driving.

Ensure the tires are properly inflated. Underinflated tires increase rolling resistance, which reduces fuel economy. Check the tire pressure regularly and inflate them to the recommended pressure listed on the driver’s side doorjamb. This simple maintenance step can make a noticeable difference.

Minimize idling time. The 48V mild-hybrid system ensures smooth and quick restarts; avoiding unnecessary idling will save fuel especially considering the premium gasoline these cars consume. If you anticipate waiting for more than a minute, turn off the engine.

Use cruise control on the highway. Maintaining a constant speed optimizes fuel efficiency, minimizing unnecessary acceleration and deceleration. Cruise control helps achieve this, leading to improved MPG on long drives. It also reduces driver fatigue.

The S500 uses a 9-speed automatic transmission. Lightly easing off the accelerator allows the transmission to shift into its higher gears as efficiently as possible. Keep in mind that the S500 isn’t a sports car and you will achieve maximum efficiency by gently accelerating to your target speed.

Explore all Mercedes Benz fuel economy data to view other models’ fuel efficiency figures. Or get specifics on S500 MPG across all years.