26 MPG combined won’t set any records, but it’s acceptable for the 2022 Mercedes-Benz E350. This isn’t a hybrid, and it’s not trying to be. The E350 is for affluent professionals and executives who value luxury, technology, and understated performance. They aren’t hyper-focused on squeezing every last mile out of a gallon of fuel, but they don’t want to be wasteful either. The E350 balances respectable efficiency with the core Mercedes-Benz attributes. These buyers prioritize a smooth, quiet ride, a meticulously crafted interior, and brand prestige. Fuel economy matters, but it’s lower on the list than comfort, safety, and brand cachet.

City and highway performance

The EPA estimates for the 2022 E350 are 23 MPG in the city and 31 MPG on the highway. The lower city figure is common for gasoline-powered vehicles; stop-and-go traffic and frequent acceleration wear on efficiency. The 31 MPG highway rating demonstrates the 2.0L turbocharged engine’s ability to deliver reasonable fuel economy when cruising. The 9-speed automatic transmission helps, keeping the engine in its optimal efficiency range for effortless highway driving. These figures reflect the E350’s ability to navigate urban landscapes and handle long-distance journeys comfortably.

Annual fuel cost

The EPA estimates the annual fuel cost for the 2022 Mercedes-Benz E350 at $2,250. This is based on driving 15,000 miles per year and assumes national average fuel prices. This number offers a benchmark for comparing the E350’s running costs against other vehicles or trims. Individual fuel costs will vary depending on driving habits, local fuel prices, and driving type (city vs. highway). However, $2,250 is a reasonable estimate of what owners can expect to spend annually on fuel.

Real-world expectations

While the EPA estimates provide a standardized benchmark, real-world fuel economy will differ. Aggressive acceleration, frequent short trips, and consistent climate control use can negatively impact MPG. Careful driving, regular maintenance, and optimized tire pressure can help owners get closer to, or exceed, the EPA figures. Expect the E350 to see numbers close to the EPA’s estimates. The car’s advanced engine management system and efficient transmission maximize fuel economy. Remember to consult the E350 MPG across all years when considering a used vehicle to compare model year performance.

How it compares

The E350’s fuel economy is competitive for a mid-size luxury sedan, but not the best. The BMW 530i achieves a similar 27 MPG combined, due to its similar 2.0L turbo engine. The Acura TLX, with its base 2.0L turbo, lags slightly behind with 25 MPG combined. The Lexus ES 350, with a V6 engine, achieves 26 MPG combined. Hybrid options exist, but target different priorities. The E350 buyer accepts decent fuel economy in exchange for Mercedes-Benz design, technology, and overall value.

Tips to maximize efficiency

Adopt a smoother driving style. Avoid aggressive acceleration and hard braking, as these consume more fuel. Anticipate traffic and maintain a steady speed. The E350’s engine management system optimizes fuel economy at a consistent pace.

Regularly check your tire pressure. Underinflated tires increase rolling resistance, which reduces fuel economy. Refer to the sticker on the driver’s side doorjamb for the recommended tire pressure. Keeping your tires properly inflated improves fuel efficiency, safety, and tire life.

Minimize idling. If you anticipate being stopped for more than a minute, turn off the engine. Modern engines restart quickly, and restarting consumes less fuel than idling. This is relevant in city driving.

Use the E350’s drive mode selector. The car offers an “Eco” or “Comfort” mode that optimizes engine and transmission settings for fuel economy. These modes may slightly reduce throttle response, but can save fuel. Learning the intricacies of all Mercedes Benz fuel economy data can help you make an informed decision.