The 2022 Lexus RX 350 L, with its 3.5L V6, gets a combined fuel economy of 22 MPG. That figure isn’t going to win any awards, but it reflects the realities of a naturally aspirated six-cylinder engine powering a relatively large, three-row luxury SUV. The RX 350 L isn’t about maximizing MPGs; it’s about providing a comfortable, reliable, and spacious vehicle for families who prioritize luxury and a smooth ride over fuel efficiency. These buyers accept the trade-off because the RX 350 L delivers on its promises.

City and highway performance

The EPA estimates the RX 350 L’s fuel economy at 19 MPG in the city and 26 MPG on the highway. That city figure is fairly typical for a vehicle of this size and powertrain configuration. Stop-and-go traffic and the inherent inefficiencies of an internal combustion engine at low speeds take their toll. The highway figure is more respectable; the eight-speed automatic transmission helps the RX 350 L cruise efficiently at higher speeds. However, remember that these numbers are just estimates. Individual driving habits and terrain will significantly impact the actual mileage you achieve.

Annual fuel cost

According to the EPA, the annual fuel cost for the 2022 Lexus RX 350 L is estimated to be $2,000. This figure is based on driving 15,000 miles per year and using national average fuel prices. While gas prices fluctuate, that $2,000 figure provides a benchmark for understanding the RX 350 L’s relative running costs. Someone who drives significantly less than 15,000 miles will spend less. If you do more highway driving you might see that number decrease due to the higher MPG on the open road.

Real-world expectations

The EPA estimates provide a useful baseline, but real-world fuel economy often varies. Many owners report similar or slightly lower numbers than the official ratings, particularly in mixed driving conditions. Aggressive driving, frequent short trips, and even the use of accessories like air conditioning can all contribute to a decrease in fuel economy. The RX 350 L isn’t particularly lightweight, and the V6 engine needs to work a bit harder when the vehicle is fully loaded with passengers and cargo, further impacting efficiency. As with any vehicle, careful driving habits will have a significant impact on your overall fuel costs.

How it compares

Compared to other three-row luxury SUVs, the RX 350 L’s fuel economy is generally in the middle of the pack. The Acura MDX, for example, achieves a similar 19 city / 26 highway MPG rating with its standard V6 engine. The Infiniti QX60 fares similarly. However, some competitors offer more efficient options. For instance, Volvo’s XC90 Recharge plug-in hybrid offers significantly better MPG in hybrid mode, although its price point is considerably higher. Buyers cross-shopping with the RX might also consider the Lincoln Aviator, but the Aviator’s turbocharged engine generally achieves slightly lower fuel economy numbers. If fuel economy is a top priority, a hybrid or plug-in hybrid powertrain is worth considering, but these come at a premium price. The RX MPG across all years shows that Lexus has never prioritized MPG over reliable, powerful engines. For all all Lexus fuel economy data, browse elsewhere on the site.

Tips to maximize efficiency

Avoid aggressive acceleration and braking. The RX 350 L’s smooth power delivery is best enjoyed with a gentle touch on the accelerator. Sudden bursts of speed and hard braking waste fuel, so try to anticipate traffic flow and maintain a steady pace.

Ensure your tires are properly inflated. Underinflated tires increase rolling resistance, which reduces fuel economy. Check your tire pressure regularly and inflate them to the recommended levels, which can be found on the sticker inside the driver’s side doorjamb.

Reduce unnecessary weight. Carrying extra cargo in the RX 350 L adds weight and increases fuel consumption. Remove any items from the vehicle that you don’t need, especially heavy objects.

Use cruise control on the highway. Maintaining a constant speed on the highway helps optimize fuel economy. Cruise control can prevent unintentional acceleration and deceleration, leading to more efficient driving.

Consider using the “Eco” driving mode. While it may slightly reduce throttle response, the Eco mode optimizes the engine and transmission settings for better fuel efficiency, especially during city driving. It’s a worthwhile feature to use during routine commutes when maximum performance isn’t required.