Lexus · 2022
IS 350 AWD 3.5L 6-cyl
✓ EPA Verified
Premium Gasoline
Compact Cars
All-Wheel Drive
City
19
MPG
Combined
22
MPG
Highway
26
MPG
Annual Fuel Cost
$2,650
Based on 15,000 miles/year · EPA estimates
vs avg gas vehicle
$500
more per year
Class Comparison — Compact Cars
Bottom 17%
Better than 17 out of 100 vehicles in its class for fuel efficiency.
This vehicle: 22 MPG
This vehicle
22 MPG
Class average
33 MPG
Class lowest
12 MPG
EPA Energy & Environment Scores
5
Energy Score
Out of 10
5
GHG Score
Out of 10
407 lbs
Annual CO₂
g/mile tailpipe CO₂
No
Start-Stop
Not equipped
Vehicle Specifications
Engine3.5L 6-cyl
TransmissionAutomatic (S6)
DriveAll-Wheel Drive
Fuel TypePremium Gasoline
Vehicle ClassCompact Cars
Engine DescSIDI & PFI
Start-StopNo
EPA Vehicle ID44536

The 2022 Lexus IS 350 AWD gets 22 MPG combined, a figure that won’t impress hypermilers, but one that arguably satisfies its target audience. No one buys an IS 350 AWD primarily for fuel efficiency; they choose it for its blend of sharp styling, engaging driving dynamics, proven Lexus reliability, and the security of all-wheel drive. The fuel economy, while not class-leading, is an accepted consequence of these attributes.

City and highway performance

The EPA estimates the IS 350 AWD will achieve 19 MPG in the city and 26 MPG on the highway. The comparatively modest highway figure is likely due to the older six-speed automatic transmission. While smooth and responsive, it lacks the extra gears found in many modern vehicles that help optimize fuel economy at cruising speeds. The city figure reflects the 3.5L V6 engine’s willingness to deliver brisk acceleration, even if it comes at the cost of efficiency. Drivers who prioritize a more relaxed driving style in urban environments may see slightly better results, but the engine’s eager nature often encourages spirited driving.

Annual fuel cost

The EPA calculates the annual fuel cost for the 2022 Lexus IS 350 AWD at $2,650. This figure is based on driving 15,000 miles per year, with an assumed fuel price reflecting national averages. It is important to understand that this is an estimate. Actual fuel costs will vary based on individual driving habits, local fuel prices, and the percentage of city versus highway driving. Drivers who rack up significantly more than 15,000 miles annually, or those who live in areas with higher fuel costs, should anticipate spending more. Conversely, those who drive less or live where fuel is cheaper may spend less than the EPA estimate. Always consult all Lexus fuel economy data to inform your decision.

Real-world expectations

While the EPA figures provide a standardized benchmark, real-world fuel economy often deviates. Owners suggest that the IS 350 AWD typically delivers figures close to the EPA estimates or slightly below, depending on driving style. Aggressive acceleration and frequent hard braking will negatively impact fuel consumption, while a gentle and consistent driving style can help achieve figures closer to the EPA’s projections. The vehicle’s all-wheel-drive system also contributes to slightly lower fuel economy compared to rear-wheel-drive models. It adds weight and introduces frictional losses, both of which impact efficiency. Keep this in mind as you browse other IS MPG across all years.

How it compares

Compared to its rivals, the IS 350 AWD’s fuel economy lands somewhere in the middle of the pack. The BMW 330i xDrive, for example, achieves a combined 28 MPG with its turbocharged four-cylinder engine. The Acura TLX SH-AWD, when equipped with its 2.0-liter turbo engine, returns around 24 MPG combined. The Mercedes-Benz C300 4MATIC manages a similar 25 MPG combined. The Cadillac CT4-V’s 2.7L Turbo engine, while offering comparable power, yields considerably lower MPG figures closer to the Lexus. Buyers still pick the Lexus often because of the naturally aspirated V6 engine’s character, the reputation for strong reliability, and the specific Lexus ownership experience, outweighing the fuel economy difference.

Tips to maximize efficiency

Maintain proper tire inflation. Underinflated tires increase rolling resistance, forcing the engine to work harder and consume more fuel. Check your tire pressures regularly and inflate them to the recommended levels found on the doorjamb sticker.

Anticipate traffic flow and avoid aggressive acceleration and braking. Gradual acceleration and smoother braking conserve momentum and reduce the amount of energy wasted. Give yourself plenty of following distance to avoid sudden stops.

Reduce unnecessary weight in the vehicle. Extra weight increases the engine’s workload, leading to higher fuel consumption. Remove any unnecessary items from the trunk and passenger compartment to lighten the load.

Minimize idling. Modern engines are generally more fuel-efficient when running than idling. If you anticipate stopping for more than a minute, switch off the engine.