The 2022 Lexus IS 350 gets 23 MPG combined, which isn’t going to win any hypermiling contests. Fuel efficiency isn’t usually the primary concern for people who buy this car, though. It’s more about a distinctive driving feeling with a connection to the road and plenty of naturally aspirated power. It’s a car for drivers who appreciate a well-sorted chassis and the smooth, linear delivery of a V6. They may sacrifice a few MPGs compared to turbocharged four-cylinder engines.

City and highway performance

The EPA estimates the IS 350 at 20 MPG in the city and 28 MPG on the highway. This difference highlights that this engine performs best when cruising. Stop-and-go traffic reveals the engine’s higher fuel consumption at lower RPMs, while highway driving allows it to run more efficiently. The eight-speed automatic transmission (S8) helps keep the engine in its sweet spot. The IS 350’s fuel efficiency is best on longer trips where constant speed is the norm.

Annual fuel cost

The EPA estimates the annual fuel cost for the 2022 Lexus IS 350 is $2,500. This is based on driving 15,000 miles per year and using national average fuel prices. It’s a useful benchmark for comparing the IS 350’s running costs against other vehicles. Individual expenses will vary based on driving habits and local fuel prices. Drivers who spend more time in congested city centers will likely see higher fuel costs annually. If you primarily drive on open highways that number may be under $2,500.

Real-world expectations

Some owners report numbers close to the EPA estimates. It’s important to understand how driving style affects fuel economy. Hard acceleration and frequent hard stops will significantly reduce MPG. Regular use of Sport mode, which alters the throttle response and shift points, will also reduce fuel mileage. Driving smoothly and anticipating traffic will help you potentially meet or slightly exceed the EPA estimates. You can explore all Lexus fuel economy data to see how the IS 350 compares to other models in the Lexus lineup. Also, check out IS MPG across all years.

How it compares

Cars like the BMW 330i (28 MPG combined), with its turbocharged four-cylinder engine, offer better fuel economy. The Mercedes-Benz C300 gets about 25 MPG combined. The Audi A4, also uses a turbocharged engine and gets 28 MPG combined. IS 350 buyers often accept this difference, prioritizing the sound and feel of a naturally aspirated V6 over maximum MPG. The Acura TLX, with its optional 2.0L turbo engine, gets 25 MPG combined and appeals to some of the same buyers.

Tips to maximize efficiency

Regular maintenance is important. Have your IS 350 get scheduled oil changes, air filter replacements, and tire rotations. Paying attention to these things will help the engine run smoothly and efficiently, improving fuel economy.

Minimize idling. Letting the engine run for no reason wastes gas. If you think you’ll be stopped for more than a minute, turn off the engine. Modern vehicles are designed to restart quickly and reliably.

Monitor your tire pressure. Underinflated tires increase rolling resistance, which reduces fuel economy. Check your tire pressure regularly and inflate them to the levels listed on the driver’s side doorjamb. Doing so ensures optimal efficiency and even tire wear.

Avoid aggressive driving. Strong acceleration and hard braking use more fuel. Drive smoothly, anticipate traffic, and keep a consistent speed when you can. Gradual acceleration and gentle braking will improve fuel efficiency and reduce wear and tear.

Use cruise control on the highway. Maintaining a constant speed is more efficient than constantly adjusting the throttle. Cruise control helps optimize fuel consumption on long highway drives. This allows the engine to settle into its most efficient operating range.