| Engine | 3.5L 6-cyl |
| Transmission | Automatic (AV-S7) |
| Drive | All-Wheel Drive |
| Fuel Type | Regular Gasoline |
| Vehicle Class | Midsize Station Wagons |
| Start-Stop | No |
| EPA Vehicle ID | 43635 |
The 2021 Nissan Murano AWD with the 3.5L V6 gets 22 MPG combined. Nissan understands that Murano buyers aren’t expecting Prius-level fuel economy. This mid-size crossover is for drivers who prioritize style, comfort, and a touch of luxury without a high price. Fuel efficiency is a consideration, but it’s secondary to the Murano’s design and smooth ride. While 22 MPG may not be exceptional, it’s often acceptable to the Murano’s target buyer.
City and highway performance
The Murano’s EPA ratings are 20 MPG in the city and 27 MPG on the highway. The city figure reflects the fuel needed for stop-and-go traffic, where the V6 engine and automatic transmission (AV-S7) work harder. The highway number shows the Murano’s ability to cruise efficiently on longer trips. The continuously variable transmission (CVT) in the Murano, while sometimes criticized for its driving feel, helps optimize fuel consumption at steady speeds, contributing to that higher highway number.
Annual fuel cost
The EPA estimates the annual fuel cost for the 2021 Nissan Murano AWD at $2,000. This is based on driving 15,000 miles per year and using national average fuel prices. Your actual costs will vary depending on your driving habits, the type of fuel you purchase, and local gas prices.
Real-world expectations
While the EPA provides standardized testing data, real-world MPG often differs. Aggressive driving, carrying heavy loads, and extreme weather can negatively impact fuel economy. Murano drivers who spend most of their time in urban environments with frequent stops and starts may see numbers closer to the city estimate, while highway drivers might achieve numbers near or even slightly above the 27 MPG rating. The best way to understand your Murano’s actual efficiency is by monitoring your own fuel consumption through trip odometers and fuel logs.
How it compares
The Murano’s fuel economy is in the middle of its class. A similarly equipped Honda Passport, with its 3.5L V6 and AWD, also achieves around 22 MPG combined. The Toyota Venza, a hybrid mid-size crossover, offers a significantly better 39 MPG combined, but the Venza prioritizes fuel efficiency over outright power. Other mid-size SUVs like the Kia Sorento (non-hybrid) will have comparable fuel economy between 24-26 MPG.
Considering all Nissan fuel economy data can provide further context, and to look at MURANO MPG across all years can also be helpful.
Tips to maximize efficiency
Smooth and steady acceleration is crucial. The Murano’s V6 responds well to gentle throttle inputs. Avoid rapidly accelerating, especially from a standstill, as this burns significantly more fuel. Anticipate traffic flow and maintain a consistent speed to minimize unnecessary acceleration and braking.
Tire pressure plays a role in fuel economy. Underinflated tires create more rolling resistance, forcing the engine to work harder. Check your tire pressure regularly and inflate them to the recommended levels, typically found on a sticker inside the driver’s side doorjamb. Even a few PSI can make a noticeable difference over time.
Reduce unnecessary weight. Carrying extra cargo in the Murano adds strain on the engine, reducing fuel efficiency. Remove any unnecessary items from the trunk and backseat; even small amounts of extra weight can add up, especially during city driving.
Minimize idling. Letting the Murano idle for extended periods wastes fuel. Modern engines warm up quickly while driving, so it’s better to start driving gently after a short idle period. Avoid excessive idling in drive-throughs or while waiting for someone.
The Murano’s all-wheel-drive system adds weight and drivetrain loss, which contributes to lower fuel economy compared to a front-wheel-drive variant (if available in a given model year). While AWD provides added traction in slippery conditions, it’s not always necessary in dry conditions. Understanding when and how the system engages can influence your overall fuel consumption.