The 2021 Mercedes-Benz E350 4matic’s combined fuel economy of 25 MPG isn’t setting any efficiency records, but for a luxury sedan focused on comfort, technology, and smooth performance, it’s acceptable. This E350 appeals to drivers who appreciate a refined experience and find the moderate fuel consumption an acceptable cost.

City and highway performance

The EPA estimates the E350 4matic gets 22 MPG in the city and 30 MPG on the highway. The city figure reflects frequent stops and starts, common in urban driving, where the 2.0L turbocharged four-cylinder engine accelerates from a standstill. The 9-speed automatic transmission tries to keep the engine in its most efficient range, but frequent acceleration consumes fuel. The E350 4matic is better on the highway. The well-tuned engine and smooth-shifting transmission allow it to cruise comfortably and efficiently, making long trips easier on your wallet.

Annual fuel cost

The EPA estimates the annual fuel cost for the 2021 Mercedes-Benz E350 4matic at $2,300. This is based on driving 15,000 miles per year and national average fuel prices. Your actual fuel costs will change depending on your driving style and local gasoline prices. Drivers who mainly take short city trips will probably exceed this estimate, while those who mainly drive on the highway may spend less. Use this as a benchmark for comparing the E350 with similar cars. For more information, browse all Mercedes Benz fuel economy data here at FuelEconomyHub.com.

Real-world expectations

EPA estimates provide a baseline, but real-world fuel economy often varies. The E350 4matic’s mileage is affected by driving style. Fast acceleration and hard braking will lower fuel economy, while smooth, careful driving can help you match or exceed the EPA estimates. Terrain matters, too. Hilly or mountainous areas generally result in lower fuel economy than flat terrain. The car’s load also affects mileage. Extra weight from passengers or cargo will reduce fuel economy, but not by much.

How it compares

Compared to other luxury sedans, the 2021 E350 4matic’s fuel economy is competitive. The BMW 530i xDrive, for example, gets about 25 MPG combined. The Audi A6 45 TFSI quattro also gets around 25 MPG. A larger engine, like the inline-six in the Mercedes-Benz E450 4matic, lowers fuel economy to about 24 MPG combined. Hybrid options like the Lexus ES 300h deliver better fuel economy, often exceeding 44 MPG combined. E350 buyers may not consider a Lexus ES; they likely prioritize the Mercedes-Benz’s performance, luxury, and brand recognition, accepting slightly lower fuel economy as a trade-off. You can compare E350 MPG across all years here.

Tips to maximize efficiency

Use “Comfort” mode for most driving. The various drive modes change the engine and transmission settings, and “Comfort” prioritizes smooth, efficient operation. “Sport” and “Sport+” modes offer faster acceleration and sharper throttle response, but they also consume more fuel.

Use the E350’s cruise control on the highway. Maintaining a constant speed helps maximize fuel efficiency. Avoid sudden acceleration and braking, as these waste fuel.

Keep your tires properly inflated. Underinflated tires increase rolling resistance, reducing fuel economy. Check your tire pressure regularly and inflate them to the pressure listed on the doorjamb.

Minimize idling. If you’re stopped for more than a minute, turn off the engine. Modern engines restart quickly and efficiently, and idling wastes fuel.

Reduce unnecessary weight. Remove any unneeded items from the trunk or backseat. Every extra pound reduces fuel economy, even if only a little.