The 2021 Mercedes-AMG CLS53 4matic Plus achieves a combined fuel economy rating of 23 MPG. This likely won’t deter buyers, because it is a sleek, powerfully styled, and genuinely quick four-door coupe with a turbocharged engine and electric motor. These buyers prioritize exclusivity, performance, and advanced technology over low fuel costs, seeing MPG as a cost for entry for the experience the CLS53 delivers.

City and highway performance

The CLS53’s official EPA ratings break down to 21 MPG in the city and 26 MPG on the highway. The city number reflects stop-and-go conditions where the CLS53’s weight and quick throttle response matter. The highway figure is more respectable, helped by the 9-speed automatic transmission that allows the engine to cruise at lower RPMs, and the efficient inline-six engine. However, even on the open road, a driver who regularly exploits the CLS53’s passing power will see a drop in fuel economy.

Annual fuel cost

The EPA estimates the annual fuel cost for the 2021 Mercedes-AMG CLS53 4matic Plus at $2,500. This is based on driving 15,000 miles per year and using the national average fuel price for premium gasoline.

While $2,500 is a significant sum, this is an estimate. Individual driving habits and local fuel prices can significantly alter the actual expense. A vehicle in this class may have higher insurance premiums and maintenance costs compared to more economy-focused cars, so fuel costs are just one piece of the overall ownership costs.

Real-world expectations

While the EPA ratings are a useful benchmark, real-world fuel economy often differs. CLS53 owners often report MPG figures within a few miles per gallon of the official estimates, but aggressive driving, frequent short trips, and heavy city traffic will invariably lead to lower numbers. Drivers who prioritize smooth acceleration and consistent highway speeds may see results at or slightly above the EPA’s estimates. Remember that driving style and conditions play a big role with a performance-oriented car like the CLS53.

How it compares

When compared to its rivals, the 2021 Mercedes-AMG CLS53 falls somewhere in the middle. The BMW M850i Gran Coupe, with its V8 engine, offers similar performance but typically achieves around 17 MPG combined. The Porsche Panamera 4S, another four-door coupe competitor, achieves around 21 MPG combined. Audi’s RS7 posts similar economy figures to the M850i with a combined 18 MPG. The CLS53’s slight fuel-economy advantage is unlikely to be a deciding factor for these buyers, as they are generally focused on performance, luxury, and brand cachet. For those looking for a slightly more efficient option without sacrificing too much excitement, the CLS53 is a good choice.

You can also compare all Mercedes Benz fuel economy data to see how this compares to the broader lineup. You can also see AMG MPG across all years.

Tips to maximize efficiency

Take it easy on initial acceleration. The CLS53’s turbocharger spools up quickly, and while that rush of power is tempting, smooth and gradual acceleration will significantly reduce fuel consumption, especially in urban environments.

Use the car’s driving modes. Select the “Comfort” or “Eco” mode in situations where performance isn’t important. These modes adjust the throttle response, transmission shift points, and other parameters to optimize fuel efficiency.

Pay attention to tire pressure. Ensure that your tires are properly inflated according to the manufacturer’s recommendations. Underinflated tires increase rolling resistance, leading to higher fuel consumption.

Anticipate traffic flow. By looking ahead and anticipating traffic slowdowns, you can avoid unnecessary braking and acceleration, which wastes fuel. Maintaining a steady speed is key to maximizing highway fuel economy.

Minimize excessive idling. Modern engines are designed to be more efficient when running than when idling. If you’re stopped for more than a minute, it’s generally more fuel-efficient to turn off the engine.