22 MPG combined isn’t award-winning, but many Lexus RX 350 AWD owners accept it. This vehicle isn’t for hypermilers. Buyers choose it for a smooth ride, a luxurious cabin, and the reliable Lexus reputation rather than segment-leading fuel efficiency. They understand this trade-off and are often willing to make it.

City and highway performance

The EPA estimates the 2021 Lexus RX 350 AWD at 19 MPG in the city and 26 MPG on the highway. The city number reflects the demands on a naturally aspirated 3.5L V6 engine in stop-and-go traffic. This engine performs well with smooth throttle application but struggles with consistent hard acceleration from a standstill. On the open road, the 26 MPG highway rating is more achievable, especially when using adaptive cruise control on long trips. The eight-speed automatic transmission helps, keeping the engine at optimal RPM for efficiency when cruising.

Annual fuel cost

The EPA estimates the annual fuel cost for the 2021 Lexus RX 350 AWD at $2,000. This is based on driving 15,000 miles per year and using national average fuel prices. This is just an estimate. Individual fuel costs will vary based on driving habits, local fuel prices, and actual annual miles driven.

Real-world expectations

Real-world MPG for the RX 350 AWD tends to be slightly below the EPA combined estimate, especially for drivers who spend most of their time in urban environments. Aggressive driving habits, frequently inducing high RPMs in the 3.5L V6, will lower fuel economy. However, drivers with mostly highway commutes and a gentle right foot can sometimes meet or even slightly exceed the 26 MPG highway estimate. Expect to see numbers in the low 20s for mixed driving conditions.

How it compares

In the competitive mid-size luxury SUV segment, the RX 350 AWD isn’t a fuel economy leader. The Acura MDX SH-AWD, for instance, achieves a similar 19 MPG city, 26 MPG highway, and 22 MPG combined despite a similar engine. The BMW X5 xDrive40i gets 21 MPG city, 25 MPG highway, and 23 MPG combined, with a more powerful turbocharged inline-six engine. Even the Volvo XC60 T6 AWD manages 20 MPG city, 27 MPG highway, and 23 MPG combined. Many RX buyers are willing to trade slightly worse fuel economy for the Lexus reputation for reliability and lower long-term maintenance costs. See RX MPG across all years to understand how it stacks up.

Tips to maximize efficiency

Gentle acceleration is key to maximizing fuel economy in the RX 350 AWD. The 3.5L V6 responds well to a light foot, and avoiding sudden bursts of speed will significantly reduce fuel consumption, particularly in city driving. Accelerate as smoothly as possible, and avoid unnecessarily hard acceleration from a standstill.

Use the Lexus Drive Mode Select system. The “Eco” mode optimizes vehicle settings, including throttle response and climate control, to prioritize fuel efficiency. While it might slightly reduce performance feel, it can make a noticeable difference in MPG, especially on longer trips. Remember to switch it back to “Normal” or “Sport” when you need a sharper response.

Ensure your tires are properly inflated and that your vehicle has all recommended maintenance. Underinflated tires increase rolling resistance, reducing fuel efficiency. Regular oil changes and air filter replacements also help engine performance and fuel economy. Find all Lexus fuel economy data to see trends across the brand.

Reduce unnecessary weight in the vehicle. Hauling extra cargo in the trunk or on the roof rack significantly impacts fuel economy. Remove any non-essential items to lighten the load and improve MPG, especially before long road trips where every MPG counts.

Consider using cruise control on the highway to maintain a consistent speed, which minimizes unnecessary acceleration and deceleration, leading to improved fuel efficiency. The RX 350 AWD’s adaptive cruise control system is especially useful in maintaining a safe following distance while improving fuel consumption.