22 MPG combined. That’s the headline figure for the 2021 Lexus IS 350 AWD with its naturally aspirated 3.5L V6. It immediately tells you something about the priorities of both Lexus and the buyers of this particular sports sedan. It’s a trade-off: character and all-weather grip for a penalty at the pump. The IS 350 AWD appeals to those who value a smooth, responsive engine, a comfortable ride, and the sure-footedness of all-wheel drive, often in regions where snow and ice are a regular occurrence. They’re willing to concede some fuel efficiency in exchange for these attributes.

City and highway performance

The EPA estimates the IS 350 AWD achieves 19 MPG in the city and 26 MPG on the highway. The city figure reflects the reality of stop-and-go traffic, where the V6 engine works harder, and the all-wheel drive system constantly juggles power distribution. The highway number, while better, is still not class-leading.

Much of this comes down to the reliable but aging six-speed automatic transmission. Modern eight or even ten-speed gearboxes, common among competitors, can keep the engine in its most efficient rev range, improving fuel economy, which the IS 350 lacks.

Annual fuel cost

The EPA calculates an annual fuel cost of $2,650 for the 2021 Lexus IS 350 AWD. This figure is based on driving 15,000 miles per year, with a specific percentage of those miles driven in the city versus highway, and using the national average fuel price when the testing was performed.

Keep in mind that fluctuating gas prices can alter the real-world cost. Also, aggressive driving habits and prolonged idling will inflate your personal fuel expenses beyond this estimate. This figure should be viewed as a guide to help compare vehicles.

Real-world expectations

While the EPA figures offer a standardized benchmark, how you drive and where you drive will significantly influence your gas mileage. Expect results close to the EPA figures with careful, moderate driving. However, if you frequently use the engine’s power for spirited acceleration or encounter heavy traffic, you’ll likely see MPG numbers closer to the 17-20 MPG range.

Winter driving conditions, common in regions where AWD is desired, can decrease fuel economy due to the increased rolling resistance of winter tires and the engine working harder in colder temperatures.

How it compares

Compared to its competitors, the fuel economy of the IS 350 AWD sits in the middle of the pack. The BMW 330i xDrive, for example, boasts 28 MPG combined, thanks to its turbocharged four-cylinder engine and eight-speed automatic. The Audi A4 quattro achieves a similar 28 MPG combined, also using a turbocharged four-cylinder and a more modern transmission. Even the Genesis G70 2.0T AWD gets a respectable 23 MPG combined. However, those opting for the IS 350 AWD likely prioritize the smooth power delivery and distinctive sound of the V6 over maximizing fuel efficiency. You can view IS MPG across all years to look at fuel economy fluctuations across generations.

Tips to maximize efficiency

Gentle acceleration and consistent speeds are crucial for maximizing fuel economy in the IS 350 AWD. Avoid abrupt starts and stops, and anticipate traffic flow to minimize unnecessary braking. The 3.5L V6 responds beautifully to a light foot, rewarding smooth driving with better fuel efficiency.

Monitor your tire pressure regularly. Underinflated tires increase rolling resistance, forcing the engine to work harder and consume more fuel. Refer to the sticker on the driver’s side doorjamb for the recommended tire pressure. You can find all Lexus fuel economy data on this site to compare figures.

Reduce unnecessary weight in the vehicle. Extra cargo adds to the car’s overall weight, impacting fuel economy, especially during city driving. Remove any items you don’t need for your daily commute or longer trips.

Consider using the car’s “ECO” mode, if equipped. This mode typically adjusts throttle response and transmission shift points, prioritizing fuel efficiency over performance. While it might slightly reduce the car’s sporty feel, it can contribute to noticeable fuel savings, mostly while commuting.

Minimize idling. If you’re stopped for more than a minute or two, turn off the engine. Modern engines are designed to restart quickly and efficiently, and idling consumes fuel without moving the vehicle. This is particularly relevant during cold starts in winter, where drivers often let the engine warm up excessively.