The 2021 Lexus IS 300 AWD, with its 3.5L V6 engine, has an official EPA fuel economy rating of 22 MPG combined. This figure isn’t going to set any fuel efficiency records, but it reflects the IS’s engaging driving experience, proven reliability, and refined character. The IS buyer is often seeking a well-built, attractive sports sedan that delivers a rewarding driving experience and the security of all-wheel drive.

City and highway performance

EPA estimates for the 2021 Lexus IS 300 AWD are 19 MPG in the city and 26 MPG on the highway. The city figure shows how responsive the engine is in stop-and-go traffic, but it’s also where the IS’s naturally aspirated V6 is not at its most efficient because it lacks a turbocharger or hybrid assistance. The highway MPG is more appealing, allowing for comfortable and relatively economical long-distance cruising. A traditional automatic transmission contributes to a highway figure that trails some of its more fuel-conscious competitors.

Annual fuel cost

The EPA estimates the annual fuel cost for the 2021 Lexus IS 300 AWD at $2,650. This is based on driving 15,000 miles per year and using national average fuel prices. This is simply an estimate, and your actual fuel costs will vary based on your driving, the fuel you use, and gas price changes. Premium fuel is recommended but not required, which may cut costs if you choose regular unleaded.

Real-world expectations

While the EPA estimates offer a baseline, real-world fuel economy may differ. Drivers who frequently drive aggressively, spend time in heavy traffic, or live in hilly areas may see fuel economy closer to the city estimate. On the other hand, those who mainly drive on the highway and drive conservatively may see figures near or even above the 26 MPG highway estimate. Check out online Lexus owner forums to know what other IS drivers experience in similar conditions.

How it compares

The Lexus IS 300 AWD isn’t the most fuel-efficient choice in its class. The BMW 330i xDrive, for example, gets a combined 28 MPG with its turbocharged four-cylinder engine, making it a more fuel-efficient option. Even the Acura TLX SH-AWD with its turbocharged four-cylinder posts a combined 25 MPG. The Audi A4 quattro with its turbo four also gets 28 MPG combined. Some buyers are willing to trade a few MPG for the IS’s naturally aspirated V6 engine and Lexus’ reliability reputation, even if IS MPG across all years isn’t the best. Those prioritizing fuel economy might choose the 330e plug-in hybrid, while loyal Lexus enthusiasts may find the IS’s features favorable, even if its MPG is less than rivals. You can find all Lexus fuel economy data on our site.

Tips to maximize efficiency

Smooth acceleration is key to maximizing fuel economy in the IS 300 AWD. Avoid quick starts and stops, and try to keep a steady speed. Allow the transmission to shift smoothly; using more throttle forces the engine to work harder and use more fuel.

Proper tire inflation improves fuel efficiency. Check your tire pressure regularly and make sure it matches what’s listed on the driver’s side doorjamb. Underinflated tires increase rolling resistance, which reduces fuel economy and makes tires wear faster.

Remove extra weight from the car. Get rid of items you don’t need because extra weight puts more strain on the engine and reduces fuel efficiency. Even a little weight can add up.

Consider using the IS’s drive modes. Eco mode, if available, adjusts the engine and transmission to prioritize fuel efficiency. While it may reduce performance a little, it can change fuel consumption, particularly when driving in the city.

Regular maintenance is important for fuel economy. Ensure your engine is properly tuned, and replace air filters and spark plugs as Lexus recommends. A well-maintained engine runs more efficiently and uses less fuel.