26 MPG combined is an acceptable figure for the 2020 Mercedes-Benz E350. It’s not the most fuel-efficient car, but it’s designed for comfort and luxury, not hypermiling. The E350 is suited to professionals and executives who want a smooth, quiet ride, a luxurious interior, and the status of the Mercedes-Benz brand. For those drivers, 26 MPG is a reasonable tradeoff.

City and highway performance

The EPA estimates are 23 MPG in the city and 32 MPG on the highway. The city figure reflects the frequent acceleration and braking of urban driving, which increases fuel consumption even with the engine’s stop/start system. The E350 performs well on the open road. The 9-speed automatic transmission allows the engine to cruise at low RPMs, saving fuel while still providing power for passing. Drivers with longer commutes or frequent highway trips will likely see numbers close to, or exceeding, the EPA’s estimates. These figures show the E350’s strength: comfortably covering long distances.

Annual fuel cost

The EPA estimates the annual fuel cost for the 2020 Mercedes-Benz E350 at $2,250. This is based on driving 15,000 miles per year with a mix of city and highway driving, using the national average fuel price at the time of calculation. Individual fuel costs will vary depending on driving habits, local fuel prices, and the type of fuel used. Premium fuel is recommended for optimal performance, but the E350 can run on regular unleaded, which could lower the annual cost but may reduce performance. Before making drastic changes, be sure to check all Mercedes Benz fuel economy data.

Real-world expectations

While the EPA provides a standard, real-world fuel economy often differs. Aggressive driving, heavy acceleration, and frequent use of Sport mode will reduce fuel efficiency. A gentle driving style, using cruise control on the highway, and minimizing idling can improve upon the EPA’s estimates. Owners who report their own mileage show a range around the official figures, and some report slight improvements under ideal conditions. The type of tires also matters, with low-rolling-resistance tires potentially increasing MPG slightly. To investigate E350 MPG across all years, consult our data.

How it compares

The E350’s fuel economy is competitive for its class. The BMW 530i, also powered by a 2.0L turbocharged four-cylinder, achieves a similar 27 MPG combined. The Audi A6 45 TFSI, with a comparable engine, gets an identical 26 MPG combined rating. The Lexus ES 350, with its V6 engine, achieves a slightly lower 26 MPG combined, though some drivers prefer its smooth, naturally aspirated power. E350 buyers are likely cross-shopping these luxury sedans, balancing fuel economy with brand, driving dynamics, and interior. The E350 is a respectable option in that market.

Tips to maximize efficiency

Gentle acceleration is critical to fuel economy in the E350. The turbocharged engine delivers torque, so there’s no need to floor the accelerator. A gradual approach will reduce fuel consumption, especially in city driving.

Use the E350’s ECO drive mode. This setting optimizes the engine and transmission for efficiency, resulting in MPG improvements. It might reduce throttle response, but the tradeoff is useful for daily commuting or longer highway trips.

Maintain proper tire inflation. Underinflated tires increase rolling resistance, reducing fuel economy. Check tire pressures and inflate them to the recommended levels, which can be found on a sticker inside the driver’s side door jamb.

Minimize idling. Modern engines are efficient even at idle, but excessive idling still wastes fuel. If you anticipate waiting for more than a minute or two, turn off the engine and restart when ready.